https://transhumanist.ru/index.php?action=history&feed=atom&title=NLK 2026-06-11T12:19:17Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=NLK&diff=5484&oldid=prev 2021-05-12T13:46:07Z

<p>Новая страница: «Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1) [LAK1] ==Publications== {{medline-entry |title=A link between maze learning...»</p> <p><b>Новая страница</b></p><div>Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1) [LAK1]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/11902125<br /> |abstract=Neuroleukin ([[NLK]]) is a multifunctional protein involved in neuronal growth and survival, cell motility and differentiation, and glucose metabolism. We report herein that hippocampal expression of [[NLK]] and its receptor gp78 is associated with maze learning in rats. First, mRNA levels of [[NLK]] and gp78 were significantly increased in hippocampi of male Fischer-344 rats following training in the Stone T-maze and the Morris water maze. Second, a parallel increase was found in hippocampal [[NLK]] and gp78 proteins after maze learning. Third, [[NLK]] and gp78 mRNA and protein expression in hippocampus was reduced in a group of aged rats that showed more errors during the acquisition of the Stone maze task as compared with young rats. Finally, application of recombinant [[NLK]] to hippocampal neurons significantly enhanced glutamate-induced ion currents, functional molecular changes that have been correlated with learning in vivo. Taken together, our results identify a novel association of hippocampal expression of [[NLK]] and its receptor gp78 with rat maze learning. Interaction of [[NLK]] with gp78 and subsequent signaling may strengthen synaptic mechanisms underlying learning and memory formation.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Gene Expression<br /> * Glucose-6-Phosphate Isomerase<br /> * Glutamic Acid<br /> * Hippocampus<br /> * Male<br /> * Maze Learning<br /> * Membrane Potentials<br /> * Neuronal Plasticity<br /> * Patch-Clamp Techniques<br /> * Rats<br /> * Rats, Inbred F344<br /> * Receptors, Autocrine Motility Factor<br /> * Receptors, Cytokine<br /> * Receptors, Somatotropin<br /> * Ubiquitin-Protein Ligases<br /> <br /> |full-text-url=https://sci-hub.do/10.1046/j.0022-3042.2001.00707.x<br /> }}</div>

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