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2021-04-29T19:16:21Z

Новая страница: «Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein)...»

Новая страница

Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein)

==Publications==

{{medline-entry
|title=Cell-type-specific expression of [[NFIX]] in the developing and adult cerebellum.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27878595
|abstract=Transcription factors from the nuclear factor one (NFI) family have been shown to play a central role in regulating neural progenitor cell differentiation within the embryonic and post-natal brain. [[NFIA]] and [[NFIB]], for instance, promote the differentiation and functional maturation of granule neurons within the cerebellum. Mice lacking Nfix exhibit delays in the development of neuronal and glial lineages within the cerebellum, but the cell-type-specific expression of this transcription factor remains undefined. Here, we examined the expression of [[NFIX]], together with various cell-type-specific markers, within the developing and adult cerebellum using both chromogenic immunohistochemistry and co-immunofluorescence labelling and confocal microscopy. In embryos, [[NFIX]] was expressed by progenitor cells within the rhombic lip and ventricular zone. After birth, progenitor cells within the external granule layer, as well as migrating and mature granule neurons, expressed [[NFIX]]. Within the adult cerebellum, [[NFIX]] displayed a broad expression profile, and was evident within granule cells, Bergmann glia, and interneurons, but not within Purkinje neurons. Furthermore, transcriptomic profiling of cerebellar granule neuron progenitor cells showed that multiple splice variants of Nfix are expressed within this germinal zone of the post-natal brain. Collectively, these data suggest that [[NFIX]] plays a role in regulating progenitor cell biology within the embryonic and post-natal cerebellum, as well as an ongoing role within multiple neuronal and glial populations within the adult cerebellum.
|mesh-terms=* Aging
* Animals
* Astrocytes
* Cell Differentiation
* Cerebellum
* Gene Expression Regulation, Developmental
* Mice, Inbred C57BL
* NFI Transcription Factors
* Neural Stem Cells
* Neurogenesis
* Neuroglia
* Neurons
|keywords=* Cerebellum
* External granular layer
* Granule neuron
* NFIX
|full-text-url=https://sci-hub.do/10.1007/s00429-016-1340-8
}}

NFIX - История изменений

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