https://transhumanist.ru/index.php?action=history&feed=atom&title=NDUFV1 2026-06-12T01:54:35Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=NDUFV1&diff=4267&oldid=prev 2021-04-29T19:09:23Z

<p>Новая страница: «NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial precursor (EC 7.1.1.2) (Complex I-51kD) (CI-51kD) (NADH dehydrogenase flavoprotein 1) (NADH-ubiquino...»</p> <p><b>Новая страница</b></p><div>NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial precursor (EC 7.1.1.2) (Complex I-51kD) (CI-51kD) (NADH dehydrogenase flavoprotein 1) (NADH-ubiquinone oxidoreductase 51 kDa subunit) [UQOR1]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24462499<br /> |abstract=Preservation of functional ability is a well-recognized marker of longevity. At a molecular level, a major determinant of the physiological decline occurring with aging is the imbalance between production and accumulation of oxidative damage to macromolecules, together with a decreased efficiency of stress response to avoid or repair such damage. In this paper we investigated the association of 38 genes (311 SNPs) belonging to the pro-antioxidant pathways with physical and cognitive performances, by analyzing single SNP and gene-based associations with Hand Grip strength (HG), Activities of Daily Living (ADL), Walking Speed (WS), Mini Mental State Examination (MMSE) and Composite Cognitive Score (CCS) in a Cohort of 1089 Danish nonagenarians. Moreover, for each gene analyzed in the pro-antioxidant pathway, we tested the influence on longitudinal survival. In the whole sample, nominal associations were found for [[TXNRD1]] variability with ADL and WS, [[NDUFS1]] and [[UCP3]] with HG and WS, [[GCLC]] and [[UCP2]] with WS (p&lt;0.05). Stronger associations although not holding the multiple comparison correction, were observed between MMSE and [[NDUFV1]], [[MT1A]] and [[GSTP1]] variability (p&lt;0.009). Moreover, we found that association between genetic variability in the pro-antioxidant pathway and functional status at old age is influenced by sex. In particular, most significant associations were observed in nonagenarian females, between HG scores and [[GLRX]] and [[UCP3]] variability, between ADL levels and [[TXNRD1]], MMSE and [[MT1A]] genetic variability. In males, a borderline statistically significant association with ADL level was found for [[UQCRFS1]] gene. Nominally significant associations in relation to survival were found in the female sample only with [[SOD2]], [[NDUFS1]], [[UCP3]] and [[TXNRD1]] variability, the latter two confirming previous observations reported in the same cohort. Overall, our work supports the evidence that genes belonging to the pro-anti-oxidant pathway are able to modulate physical and cognitive performance after the ninth decade of life, finally influencing extreme survival. <br /> |mesh-terms=* Activities of Daily Living<br /> * Aged<br /> * Aged, 80 and over<br /> * Cognition<br /> * Female<br /> * Humans<br /> * Male<br /> * Oxidative Stress<br /> * Polymorphism, Single Nucleotide<br /> |keywords=* 1905 Danish Cohort<br /> * Aging<br /> * Functional status<br /> * Oxidative stress<br /> * Survival at old age<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050201<br /> }}</div>

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