https://transhumanist.ru/index.php?action=history&feed=atom&title=NDRG4NDRG4 - История изменений2026-06-17T10:46:09ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=NDRG4&diff=5447&oldid=prevOdysseusBot: Новая страница: «Protein NDRG4 (Brain development-related molecule 1) (N-myc downstream-regulated gene 4 protein) (Vascular smooth muscle cell-associated protein 8) (SMAP-8) [BDM1...»2021-05-12T13:44:23Z<p>Новая страница: «Protein NDRG4 (Brain development-related molecule 1) (N-myc downstream-regulated gene 4 protein) (Vascular smooth muscle cell-associated protein 8) (SMAP-8) [BDM1...»</p>
<p><b>Новая страница</b></p><div>Protein NDRG4 (Brain development-related molecule 1) (N-myc downstream-regulated gene 4 protein) (Vascular smooth muscle cell-associated protein 8) (SMAP-8) [BDM1] [KIAA1180]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Molecular characterization of [[NDRG4]]/Bdm1 protein isoforms that are differentially regulated during rat brain development.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/11978392<br />
|abstract=We previously reported the identification of a novel gene, Bdm1/[[NDRG4]], that was expressed predominantly in the postnatal rat brain and might possibly play a role in this process. We describe here the characterization of a [[NDRG4]] protein in a developing and maturing rat brain. Antibody raised against glutathione S-transferase (GST)-[[NDRG4]] fusion protein recognized four protein species of 38, 39, 41, and 45 kDa on Western blotting of proteins from differently staged rat brains. The 38-kDa form was revealed after birth, and the amount of this species peaked on postnatal day 15. The 39-kDa form became detectable after postnatal week 6. The 41-kDa form appeared late in embryogenesis, increased by postnatal day 15, and disappeared at postnatal week 6. The 45-kDa form was abundant during the late embryonic period and slightly decreased after birth. Subcellular fractionation of cerebra indicated that the [[NDRG4]] protein was distributed mainly in the mitochondria and endoplasmic reticulum (ER). Detergent solubility assays and protease susceptibility demonstrated that in the ER [[NDRG4]] protein is membrane-associated and luminally oriented. The 45-kDa isoform was induced during [[NGF]]-mediated neuronal differentiation of PC12 cells, but not by tunicamycin which causes ER stress. Differential expressions of [[NDRG4]] protein isoforms may be a mechanism for modifying the [[NDRG4]] function and for the formation of a functioning nervous system.<br />
|mesh-terms=* Aging<br />
* Amino Acid Sequence<br />
* Animals<br />
* Brain<br />
* Cell Differentiation<br />
* DNA, Complementary<br />
* Endoplasmic Reticulum<br />
* Gene Expression Regulation, Developmental<br />
* Molecular Sequence Data<br />
* Muscle Proteins<br />
* Nerve Tissue Proteins<br />
* Neurons<br />
* PC12 Cells<br />
* Protein Isoforms<br />
* Rats<br />
* Reverse Transcriptase Polymerase Chain Reaction<br />
* Subcellular Fractions<br />
* Tissue Distribution<br />
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|full-text-url=https://sci-hub.do/10.1016/s0165-3806(02)00303-6<br />
}}</div>OdysseusBot