https://transhumanist.ru/index.php?action=history&feed=atom&title=NALCN 2026-11-08T15:01:20Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=NALCN&diff=5251&oldid=prev 2021-05-12T13:36:02Z

<p>Новая страница: «Sodium leak channel non-selective protein (CanIon) (Voltage gated channel-like protein 1) [VGCNL1] ==Publications== {{medline-entry |title=A sodium leak current...»</p> <p><b>Новая страница</b></p><div>Sodium leak channel non-selective protein (CanIon) (Voltage gated channel-like protein 1) [VGCNL1]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=A sodium leak current regulates pacemaker activity of adult central pattern generator neurons in Lymnaea stagnalis.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21526173<br /> |abstract=The resting membrane potential of the pacemaker neurons is one of the essential mechanisms underlying rhythm generation. In this study, we described the biophysical properties of an uncharacterized channel (U-type channel) and investigated the role of the channel in the rhythmic activity of a respiratory pacemaker neuron and the respiratory behaviour in adult freshwater snail Lymnaea stagnalis. Our results show that the channel conducts an inward leak current carried by Na( ) (I(Leak-Na)). The I(Leak-Na) contributed to the resting membrane potential and was required for maintaining rhythmic action potential bursting activity of the identified pacemaker RPeD1 neurons. Partial knockdown of the U-type channel suppressed the aerial respiratory behaviour of the adult snail in vivo. These findings identified the Na( ) leak conductance via the U-type channel, likely a [[NALCN]]-like channel, as one of the fundamental mechanisms regulating rhythm activity of pacemaker neurons and respiratory behaviour in adult animals.<br /> |mesh-terms=* Aging<br /> * Amino Acid Sequence<br /> * Animals<br /> * Behavior, Animal<br /> * Biological Clocks<br /> * Calcium<br /> * Cell Membrane<br /> * Cell Separation<br /> * Electricity<br /> * Extracellular Space<br /> * Gadolinium<br /> * Gene Knockdown Techniques<br /> * Ion Channel Gating<br /> * Lymnaea<br /> * Membrane Potentials<br /> * Molecular Sequence Data<br /> * Neurons<br /> * RNA, Double-Stranded<br /> * Sequence Alignment<br /> * Sodium Channels<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079709<br /> }}</div>

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