https://transhumanist.ru/index.php?action=history&feed=atom&title=MYSM1 2026-04-12T19:42:57Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=MYSM1&diff=4424&oldid=prev 2021-04-29T19:17:31Z

<p>Новая страница: «Deubiquitinase MYSM1 (EC 3.4.19.-) (2A-DUB) (Myb-like, SWIRM and MPN domain-containing protein 1) [KIAA1915] ==Publications== {{medline-entry |title=<a href="/MYSM1" title="MYSM1">MYSM1</a> S...»</p> <p><b>Новая страница</b></p><div>Deubiquitinase MYSM1 (EC 3.4.19.-) (2A-DUB) (Myb-like, SWIRM and MPN domain-containing protein 1) [KIAA1915]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=[[MYSM1]] Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33240758<br /> |abstract=Aging is a universal feature of life that is a major focus of scientific research and a risk factor in many diseases. A comprehensive understanding of the cellular and molecular mechanisms of aging are critical to the prevention of diseases associated with the aging process. Here, it is shown that [[MYSM1]] is a key suppressor of aging and aging-related pathologies. [[MYSM1]] functionally represses cellular senescence and the aging process in human and mice primary cells and in mice organs. [[MYSM1]] mechanistically attenuates the aging process by promoting DNA repair processes. Remarkably, [[MYSM1]] deficiency facilitates the aging process and reduces lifespan, whereas [[MYSM1]] over-expression attenuates the aging process and increases lifespan in mice. The functional role of [[MYSM1]] is demonstrated in suppressing the aging process and prolonging lifespan. [[MYSM1]] is a key suppressor of aging and may act as a potential agent for the prevention of aging and aging-associated diseases.<br /> <br /> |keywords=* DNA repair<br /> * Myb‐like, SWIRM, and MPN domains‐containing protein 1 (MYSM1)<br /> * aging<br /> * senescence<br /> * senescence‐associated secretory phenotype (SASP)<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675055<br /> }}</div>

OdysseusBot