https://transhumanist.ru/index.php?action=history&feed=atom&title=MTA3 2026-04-05T06:09:13Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=MTA3&diff=5442&oldid=prev 2021-05-12T13:44:11Z

<p>Новая страница: «Metastasis-associated protein MTA3 [KIAA1266] ==Publications== {{medline-entry |title=<a href="/CHD5" title="CHD5">CHD5</a>, a brain-specific paralog of Mi2 chromatin remodeling enzymes, re...»</p> <p><b>Новая страница</b></p><div>Metastasis-associated protein MTA3 [KIAA1266]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=[[CHD5]], a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21931736<br /> |abstract=[[CHD5]] is frequently deleted in neuroblastoma and is a tumor suppressor gene. However, little is known about the role of [[CHD5]] other than it is homologous to chromatin remodeling ATPases. We found [[CHD5]] mRNA was restricted to the brain; by contrast, most remodeling ATPases were broadly expressed. [[CHD5]] protein isolated from mouse brain was associated with [[HDAC2]], p66ß, [[MTA3]] and RbAp46 in a megadalton complex. [[CHD5]] protein was detected in several rat brain regions and appeared to be enriched in neurons. [[CHD5]] protein was predominantly nuclear in primary rat neurons and brain sections. Microarray analysis revealed genes that were upregulated and downregulated when [[CHD5]] was depleted from primary neurons. [[CHD5]] depletion altered expression of neuronal genes, transcription factors, and brain-specific subunits of the SWI/SNF remodeling enzyme. Expression of gene sets linked to aging and Alzheimer&#039;s disease were strongly altered by [[CHD5]] depletion from primary neurons. Chromatin immunoprecipitation revealed [[CHD5]] bound to these genes, suggesting the regulation was direct. Together, these results indicate that [[CHD5]] protein is found in a NuRD-like multi-protein complex. [[CHD5]] expression is restricted to the brain, unlike the closely related family members [[CHD3]] and [[CHD4]]. [[CHD5]] regulates expression of neuronal genes, cell cycle genes and remodeling genes. [[CHD5]] is linked to regulation of genes implicated in aging and Alzheimer&#039;s disease.<br /> |mesh-terms=* Aging<br /> * Alzheimer Disease<br /> * Animals<br /> * Brain<br /> * Chromatin<br /> * Chromatin Immunoprecipitation<br /> * DNA Helicases<br /> * Gene Expression Profiling<br /> * Gene Expression Regulation, Enzymologic<br /> * Humans<br /> * Mi-2 Nucleosome Remodeling and Deacetylase Complex<br /> * Mice<br /> * Multiprotein Complexes<br /> * Neurons<br /> * Oligonucleotide Array Sequence Analysis<br /> * Rats<br /> * Trans-Activators<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172237<br /> }}</div>

OdysseusBot