https://transhumanist.ru/index.php?action=history&feed=atom&title=MT1MMT1M - История изменений2026-06-07T22:41:10ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=MT1M&diff=4499&oldid=prevOdysseusBot: Новая страница: «Metallothionein-1M (MT-1M) (Metallothionein-IM) (MT-IM) [MT1K] ==Publications== {{medline-entry |title=A novel strain of Lactobacillus mucosae isolated from a G...»2021-04-29T19:21:06Z<p>Новая страница: «Metallothionein-1M (MT-1M) (Metallothionein-IM) (MT-IM) [MT1K] ==Publications== {{medline-entry |title=A novel strain of Lactobacillus mucosae isolated from a G...»</p>
<p><b>Новая страница</b></p><div>Metallothionein-1M (MT-1M) (Metallothionein-IM) (MT-IM) [MT1K]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=A novel strain of Lactobacillus mucosae isolated from a Gaotian villager improves in vitro and in vivo antioxidant as well as biological properties in D-galactose-induced aging mice.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26709186<br />
|abstract=Twelve isolates isolated from the gastrointestinal tracts of Gaotian villagers in China, who had a lifespan of 92 yr, were examined for their antioxidants using free radical scavenging activity and 2,2-diphenyl-1-picrylhydrazyl. Three strains (i.e., Lactobacillus mucosae LMU1001, and Lactobacillus plantarum LPL0902 and LPL0302) were selected as candidates to prepare yogurt for testing their antioxidants in a model of d-galactose-induced aging mice, with vitamin C as a positive control. The results showed that L. mucosae LMU1001 was the best strain, which had similar in vivo antioxidant activity as vitamin C. A significant increase was found in the activities of glutathione peroxidase in serum and total superoxide dismutase in the liver, and a decrease in the level of malondialdehyde in serum. Regarding mRNA expression level detected quantitatively by real-time PCR, we observed that L. mucosae LMU1001 significantly upregulated antioxidant genes (i.e., [[MT1A]] and [[MT1M]] in HT-29 and Caco-2) and those genes (i.e., MT1, MT2, GPx1, and GPx2) in the intestinal tract of the model mice. Hence, this strain could be considered as a potential probiotic lactic acid bacterium for improving antioxidant levels in functional foods. <br />
|mesh-terms=* Aged, 80 and over<br />
* Aging<br />
* Animals<br />
* Antioxidants<br />
* Caco-2 Cells<br />
* China<br />
* Functional Food<br />
* Galactose<br />
* Glutathione Peroxidase<br />
* Humans<br />
* Intestines<br />
* Lactobacillus<br />
* Lactobacillus plantarum<br />
* Liver<br />
* Longevity<br />
* Malondialdehyde<br />
* Mice<br />
* Models, Animal<br />
* Probiotics<br />
* Superoxide Dismutase<br />
|keywords=* 2,2-diphenyl-1-picrylhydrazyl<br />
* antioxidant activity<br />
* d-galactose-induced aging mice<br />
* hydroxyl radical<br />
* reducing power<br />
|full-text-url=https://sci-hub.do/10.3168/jds.2015-10265<br />
}}</div>OdysseusBot