https://transhumanist.ru/index.php?action=history&feed=atom&title=MPG 2026-06-22T03:40:07Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=MPG&diff=4814&oldid=prev 2021-04-29T19:36:15Z

<p>Новая страница: «DNA-3-methyladenine glycosylase precursor (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase)...»</p> <p><b>Новая страница</b></p><div>DNA-3-methyladenine glycosylase precursor (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) [AAG] [ANPG] [MID1]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E2 in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26981526<br /> |abstract=The effect of Menoprogen ([[MPG]]) on ovarian granulosa cell ([[GC]]) apoptosis was investigated in vitro and in vivo in an aged rat model of menopause. Intragastric administration of Menoprogen or estradiol valerate to 14-month-old senile female rats for eight weeks increased plasma E2 levels, as well as the weight of both ovarian and uterine tissues. Flow cytometric (FCM) analysis of isolated [[GC]]s from [[MPG]]-treated aged rats showed reductions in the G0/G1 ratio and apoptotic peaks. Isolated [[GC]]s also exhibited an increase in cell size and the number of cytoplastic organelles and intracellular gap junctions, the reappearance of secretory granules, and a lack of apoptotic bodies as determined by TEM. Results from a TdT-mediated dUTP nick end-labeling (TUNEL) assay revealed a reduction in TUNEL-positive [[GC]]s after [[MPG]] treatment. Immunohistochemical analysis showed a downregulation of proapoptotic Bax proteins and an upregulation of antiapoptotic Bcl-2 proteins. The addition of [[MPG]]-medicated serum to the media of cultured [[GC]]s also reduced cadmium chloride-induced apoptosis and downregulated caspase-3 protein expression. This work demonstrates that Menoprogen inhibits [[GC]] apoptosis in aged female rats and thereby increases E2 production. This represents a novel mechanism of action for this herbal medicine in the treatment of menopausal symptoms. <br /> |mesh-terms=* Aging<br /> * Animals<br /> * Apoptosis<br /> * Disease Models, Animal<br /> * Drugs, Chinese Herbal<br /> * Female<br /> * Granulosa Cells<br /> * Humans<br /> * Menopause<br /> * Ovarian Follicle<br /> * Rats<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769746<br /> }}</div>

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