https://transhumanist.ru/index.php?action=history&feed=atom&title=MECOM 2026-04-12T06:20:24Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=MECOM&diff=4738&oldid=prev 2021-04-29T19:32:37Z

<p>Новая страница: «Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelod...»</p> <p><b>Новая страница</b></p><div>Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1) [EVI1] [MDS1] [PRDM3]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29603369<br /> |abstract=Patients with inflammatory bowel disease (IBD) are at a high risk of low bone mineral density (BMD). Reportedly, clinical and genetic factors cause low BMD in Caucasians; however, studies in non-Caucasian populations remain scarce. Clinical risk factors for low BMD were investigated in 266 Japanese patients with IBD, and a genome-wide association analysis (GWAS) was performed using linear regression with associated clinical factors as covariates. Genotyping was performed using a population-optimized genotyping array (Japonica array ). After quality control, the genotype data of 4 384 682 single-nucleotide polymorphisms (SNPs) from 254 patients with IBD were used for GWAS. Body mass index, age, and disease duration were independently associated with the BMD of the femoral neck (P = 1.41E - 13, 1.04E - 5, and 1.58E - 3, respectively), and body mass index and sex were associated with the BMD of the lumbar spine (P = 6.90E - 10 and 6.84E - 3, respectively). In GWAS, 118 and 42 candidate SNPs of the femoral neck and lumbar spine, respectively, were identified. Among 118, 111 candidate SNPs of the femoral neck were located within the [[SLC22A23]] gene, which is a known IBD susceptibility gene (minimum P = 1.42E - 07). Among 42, 18 candidate SNPs of the lumbar spine were located within the [[MECOM]] gene, which is associated with osteopenia (minimum P = 5.86E - 07). Interestingly, none of the known loci showed a significant association with BMD. Although clinical risk factors for low BMD in IBD were similar to those in the general population, genetic risk factors were rather different.<br /> |mesh-terms=* Adult<br /> * Aged<br /> * Aged, 80 and over<br /> * Aging<br /> * Asian Continental Ancestry Group<br /> * Body Mass Index<br /> * Bone Density<br /> * Bone Diseases, Metabolic<br /> * Female<br /> * Femur Neck<br /> * Genetic Predisposition to Disease<br /> * Genome-Wide Association Study<br /> * Genotype<br /> * Humans<br /> * Inflammatory Bowel Diseases<br /> * Lumbar Vertebrae<br /> * MDS1 and EVI1 Complex Locus Protein<br /> * Male<br /> * Middle Aged<br /> * Organic Anion Transporters<br /> * Polymorphism, Single Nucleotide<br /> * Risk Factors<br /> * Sex Characteristics<br /> * Young Adult<br /> |keywords=* genome-wide association analysis<br /> * inflammatory bowel disease genetics<br /> * osteoporosis<br /> |full-text-url=https://sci-hub.do/10.1111/jgh.14149<br /> }}</div>

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