https://transhumanist.ru/index.php?action=history&feed=atom&title=MCM6 2026-06-20T13:14:57Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=MCM6&diff=4396&oldid=prev 2021-04-29T19:16:00Z

<p>Новая страница: «DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) ==Publications== {{medline-entry |title=Changes in <a href="/MCM2" title="MCM2">MCM2</a>-7 proteins at senescence. |pubmed-url=...»</p> <p><b>Новая страница</b></p><div>DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Changes in [[MCM2]]-7 proteins at senescence.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31092751<br /> |abstract=Cellular aging is characterized by the loss of DNA replication capability and is mainly brought about by various changes in chromatin structure. Here, we examined changes in [[MCM2]]-7 proteins, which act as a replicative DNA helicase, during aging of human WI38 fibroblasts at the single-cell level. We used nuclear accumulation of p21 as a marker of senescent cells, and examined changes in [[MCM2]]-7 by western blot analysis. First, we found that senescent cells are enriched for cells with a DNA content higher than 4N. Second, the levels of [[MCM2]], [[MCM3]], [[MCM4]] and [[MCM6]] proteins decreased in senescent cells. Third, cytoplasmic localization of [[MCM2]] and [[MCM7]] was observed in senescent cells, from an analysis of [[MCM2]]-7 except for [[MCM5]]. Consistent with this finding, fragmented [[MCM2]] was predominant in these cells. These age-dependent changes in [[MCM2]]-7, a protein complex that directly affects cellular DNA replication, may play a critical role in cellular senescence.<br /> |mesh-terms=* Cell Cycle Proteins<br /> * Cellular Senescence<br /> * DNA Replication<br /> * Gene Expression Regulation<br /> * Humans<br /> * Minichromosome Maintenance Complex Component 2<br /> * Minichromosome Maintenance Complex Component 3<br /> * Minichromosome Maintenance Complex Component 4<br /> * Minichromosome Maintenance Complex Component 6<br /> * Minichromosome Maintenance Complex Component 7<br /> * Multiprotein Complexes<br /> * Single-Cell Analysis<br /> * p21-Activated Kinases<br /> |keywords=* DNA content<br /> * MCM2–7 proteins<br /> * cellular aging<br /> * cellular localization<br /> * protein degradation<br /> |full-text-url=https://sci-hub.do/10.1266/ggs.18-00062<br /> }}</div>

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