https://transhumanist.ru/index.php?action=history&feed=atom&title=MBTD1 2026-05-14T22:50:39Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=MBTD1&diff=3931&oldid=prev 2021-04-29T18:52:18Z

<p>Новая страница: «MBT domain-containing protein 1 ==Publications== {{medline-entry |title=LncRNA <a href="/index.php?title=TTN&amp;action=edit&amp;redlink=1" class="new" title="TTN (страница не существует)">TTN</a>-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR...»</p> <p><b>Новая страница</b></p><div>MBT domain-containing protein 1<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=LncRNA [[TTN]]-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/[[MBTD1]] axis.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31600142<br /> |abstract=To explore the mechanism by which long non-coding RNA (lncRNA) [[TTN]]-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the microRNA miR-134-5p/malignant brain tumour domain containing 1 ([[MBTD1]]) axis. The lncRNA [[TTN]]-AS1 was highly expressed in osteosarcoma and was associated with poor prognosis. The lncRNA [[TTN]]-AS1 promoted cell viability and inhibited apoptosis. MiR-134-5p targeted [[MBTD1]], which was regulated by lncRNA [[TTN]]-AS1. [[MBTD1]] was highly expressed in osteosarcoma and was associated with poor prognosis. [[MBTD1]] promoted cell viability and inhibited apoptosis, and knockdown of [[MBTD1]] reversed the cancer-promoting effects of lncRNA [[TTN]]-AS1. Downregulation of lncRNA [[TTN]]-AS1 reduced drug resistance. In osteosarcoma, lncRNA [[TTN]]-AS1 promoted the expression of [[MBTD1]] by targeting miR-134-5p and regulated cell growth, apoptosis and drug resistance. The expression characteristics of genes in osteosarcoma patients were analysed using bioinformatics. Plasmid transfection technology was applied to silence or overexpress lncRNA [[TTN]]-AS1, miR-134-5p and [[MBTD1]]. Western blotting and quantitative polymerase chain reaction (qPCR) were used to detect protein and RNA, respectively. A cell counting kit 8 (CCK-8) and flow cytometry were used to detect cell viability and apoptosis. The effects of lncRNA [[TTN]]-AS1 and [[MBTD1]] on osteosarcoma in vivo were studied by using a tumour burden assay.<br /> |mesh-terms=* Aging<br /> * Apoptosis<br /> * Brain Neoplasms<br /> * Cell Line, Tumor<br /> * Cell Proliferation<br /> * Chromosomal Proteins, Non-Histone<br /> * Computational Biology<br /> * Drug Resistance<br /> * Gene Expression Regulation, Neoplastic<br /> * Humans<br /> * MicroRNAs<br /> * Osteosarcoma<br /> * RNA, Long Noncoding<br /> |keywords=* aging and age-related diseases<br /> * lncRNA TTN-AS1<br /> * malignant brain tumour domain containing protein 1<br /> * miR-134-5p<br /> * osteosarcoma<br /> * resistance<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814585<br /> }}</div>

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