https://transhumanist.ru/index.php?action=history&feed=atom&title=MBIP 2026-04-08T13:51:56Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=MBIP&diff=5141&oldid=prev 2021-05-12T13:30:59Z

<p>Новая страница: «MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein) [BM-015] ==Publications== {{medline-entr...»</p> <p><b>Новая страница</b></p><div>MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein) [BM-015]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Long-term caloric restriction ameliorates the decline in diastolic function in humans.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16412867<br /> |abstract=We determined whether caloric restriction (CR) has cardiac-specific effects that attenuate the established aging-associated impairments in diastolic function (DF). Caloric restriction retards the aging process in small mammals; however, no information is available on the effects of long-term CR on human aging. In healthy individuals, Doppler echocardiography has established the pattern of aging-associated DF impairment, whereas little change is observed in systolic function (SF). Diastolic function was assessed in 25 subjects (age 53 /- 12 years) practicing CR for 6.5 /- 4.6 years and 25 age- and gender-matched control subjects consuming Western diets. Diastolic function was quantified by transmitral flow, Doppler tissue imaging, and model-based image processing ([[MBIP]]) of E waves. C-reactive protein ([[CRP]]), tumor necrosis factor-alpha ([[TNF]]-alpha), and transforming growth factor-beta1 (TGF-beta1) were also measured. No difference in SF was observed between groups; however, standard transmitral Doppler flow DF indexes of the CR group were similar to those of younger individuals, and [[MBIP]]-based, flow-derived DF indexes, reflecting chamber viscoelasticity and stiffness, were significantly lower than in control subjects. Blood pressure, serum [[CRP]], [[TNF]]-alpha, and TGF-beta(1) levels were significantly lower in the CR group (102 /- 10/61 /- 7 mm Hg, 0.3 /- 0.3 mg/l, 0.8 /- 0.5 pg/ml, 29.4 /- 6.9 ng/ml, respectively) compared with the Western diet group (131 /- 11/83 /- 6 mm Hg, 1.9 /- 2.8 mg/l, 1.5 /- 1.0 pg/ml, 35.4 /- 7.1 ng/ml, respectively). Caloric restriction has cardiac-specific effects that ameliorate aging-associated changes in DF. These beneficial effects on cardiac function might be mediated by the effect of CR on blood pressure, systemic inflammation, and myocardial fibrosis.<br /> |mesh-terms=* Adult<br /> * Aged<br /> * Aged, 80 and over<br /> * Aging<br /> * C-Reactive Protein<br /> * Caloric Restriction<br /> * Cross-Sectional Studies<br /> * Diastole<br /> * Echocardiography, Doppler<br /> * Female<br /> * Humans<br /> * Image Processing, Computer-Assisted<br /> * Male<br /> * Middle Aged<br /> * Systole<br /> * Transforming Growth Factor beta<br /> * Transforming Growth Factor beta1<br /> * Tumor Necrosis Factor-alpha<br /> <br /> |full-text-url=https://sci-hub.do/10.1016/j.jacc.2005.08.069<br /> }}</div>

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