https://transhumanist.ru/index.php?action=history&feed=atom&title=MARS2MARS2 - История изменений2026-11-09T14:30:05ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=MARS2&diff=5737&oldid=prevOdysseusBot: Новая страница: «Methionine--tRNA ligase, mitochondrial precursor (EC 6.1.1.10) (Methionyl-tRNA synthetase 2) (Mitochondrial methionyl-tRNA synthetase) (MtMetRS) ==Publications==...»2021-05-12T13:57:30Z<p>Новая страница: «Methionine--tRNA ligase, mitochondrial precursor (EC 6.1.1.10) (Methionyl-tRNA synthetase 2) (Mitochondrial methionyl-tRNA synthetase) (MtMetRS) ==Publications==...»</p>
<p><b>Новая страница</b></p><div>Methionine--tRNA ligase, mitochondrial precursor (EC 6.1.1.10) (Methionyl-tRNA synthetase 2) (Mitochondrial methionyl-tRNA synthetase) (MtMetRS)<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22448145<br />
|abstract=An increasing number of genes required for mitochondrial biogenesis, dynamics, or function have been found to be mutated in metabolic disorders and neurological diseases such as Leigh Syndrome. In a forward genetic screen to identify genes required for neuronal function and survival in Drosophila photoreceptor neurons, we have identified mutations in the mitochondrial methionyl-tRNA synthetase, Aats-met, the homologue of human [[MARS2]]. The fly mutants exhibit age-dependent degeneration of photoreceptors, shortened lifespan, and reduced cell proliferation in epithelial tissues. We further observed that these mutants display defects in oxidative phosphorylation, increased Reactive Oxygen Species (ROS), and an upregulated mitochondrial Unfolded Protein Response. With the aid of this knowledge, we identified [[MARS2]] to be mutated in Autosomal Recessive Spastic Ataxia with Leukoencephalopathy (ARSAL) patients. We uncovered complex rearrangements in the [[MARS2]] gene in all ARSAL patients. Analysis of patient cells revealed decreased levels of [[MARS2]] protein and a reduced rate of mitochondrial protein synthesis. Patient cells also exhibited reduced Complex I activity, increased ROS, and a slower cell proliferation rate, similar to Drosophila Aats-met mutants.<br />
|mesh-terms=* Adolescent<br />
* Adult<br />
* Animals<br />
* Ataxia<br />
* Cell Proliferation<br />
* Child<br />
* Child, Preschool<br />
* Drosophila<br />
* Drosophila Proteins<br />
* Electron Transport<br />
* Electroretinography<br />
* Female<br />
* Gene Expression Regulation, Enzymologic<br />
* HEK293 Cells<br />
* Humans<br />
* Leukoencephalopathies<br />
* Longevity<br />
* Male<br />
* Methionine-tRNA Ligase<br />
* Middle Aged<br />
* Mitochondria<br />
* Mitochondrial Proteins<br />
* Muscles<br />
* Mutation<br />
* Neurodegenerative Diseases<br />
* Oxidative Phosphorylation<br />
* Pedigree<br />
* Phenotype<br />
* Photoreceptor Cells<br />
* Reactive Oxygen Species<br />
* Retina<br />
* Unfolded Protein Response<br />
* Young Adult<br />
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|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308940<br />
}}</div>OdysseusBot