https://transhumanist.ru/index.php?action=history&feed=atom&title=LRPAP1LRPAP1 - История изменений2026-08-12T01:42:11ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=LRPAP1&diff=5648&oldid=prevOdysseusBot: Новая страница: «Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) [A2MRAP]...»2021-05-12T13:53:41Z<p>Новая страница: «Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) [A2MRAP]...»</p>
<p><b>Новая страница</b></p><div>Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) [A2MRAP]<br />
<br />
==Publications==<br />
<br />
{{medline-entry<br />
|title=Allelic frequencies at the [[ACE]] and [[LRPAP1]] loci suggest age-related relationships in a northern Italian population.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/17536759<br />
|abstract=The present work attempts to determine the distribution of [[ACE]] and [[LRPAP1]] genotypes and allele frequencies in a sample of the population of north-western Italy and to examine the age-related association of these polymorphisms. [[ACE]] D allele frequency found in this work further confirms data obtained in previous studies of Northern Italian populations. Regarding the [[LRPAP1]] gene, high frequencies of the deleted allele in European populations were also confirmed. In order to analyse the relationship between [[ACE]] and [[LRPAP1]] gene polymorphisms and age, the sample was subdivided into four age groups: 1-30 (n= 99), 31-50 (n= 165), 51-79 (n= 146) and 80-100 years old (n= 57). For the [[ACE]] gene, significant difference in D/D genotype frequency was found only between the younger and the 51-79 age groups (p<0.05), the latter showing the lower frequency value. Significant differences were found, for both the I/D and D/D [[LRPAP1]] genotypes, between the first and the second age group (p < 0.02) and between the first and the third age group (p < 0.01), with the 51-79 age group showing the higher D/D and the lower I/D genotype frequency values.<br />
|mesh-terms=* Adolescent<br />
* Adult<br />
* Aged<br />
* Aged, 80 and over<br />
* Aging<br />
* Alzheimer Disease<br />
* Child<br />
* Child, Preschool<br />
* Coronary Artery Disease<br />
* European Continental Ancestry Group<br />
* Female<br />
* Gene Frequency<br />
* Genotype<br />
* Humans<br />
* Infant<br />
* Italy<br />
* LDL-Receptor Related Protein-Associated Protein<br />
* Male<br />
* Middle Aged<br />
* Peptidyl-Dipeptidase A<br />
* Polymorphism, Genetic<br />
<br />
|full-text-url=https://sci-hub.do/10.1080/03014460601079845<br />
}}</div>OdysseusBot