https://transhumanist.ru/index.php?action=history&feed=atom&title=LRP2LRP2 - История изменений2026-04-14T03:19:33ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=LRP2&diff=4078&oldid=prevOdysseusBot: Новая страница: «Low-density lipoprotein receptor-related protein 2 precursor (LRP-2) (Glycoprotein 330) (gp330) (Megalin) ==Publications== {{medline-entry |title=Single-Cell Tr...»2021-04-29T18:59:20Z<p>Новая страница: «Low-density lipoprotein receptor-related protein 2 precursor (LRP-2) (Glycoprotein 330) (gp330) (Megalin) ==Publications== {{medline-entry |title=Single-Cell Tr...»</p>
<p><b>Новая страница</b></p><div>Low-density lipoprotein receptor-related protein 2 precursor (LRP-2) (Glycoprotein 330) (gp330) (Megalin)<br />
<br />
==Publications==<br />
<br />
{{medline-entry<br />
|title=Single-Cell Transcriptomics Characterizes Cell Types in the Subventricular Zone and Uncovers Molecular Defects Impairing Adult Neurogenesis.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30485812<br />
|abstract=Neural stem cells (NSCs) contribute to plasticity and repair of the adult brain. Niches harboring NSCs regulate stem cell self-renewal and differentiation. We used comprehensive and untargeted single-cell RNA profiling to generate a molecular cell atlas of the largest germinal region of the adult mouse brain, the subventricular zone (SVZ). We characterized >20 neural and non-neural cell types and gained insights into the dynamics of neurogenesis by predicting future cell states based on computational analysis of RNA kinetics. Furthermore, we applied our single-cell approach to document decreased numbers of NSCs, reduced proliferation activity of progenitors, and perturbations in Wnt and BMP signaling pathways in mice lacking [[LRP2]], an endocytic receptor required for SVZ maintenance. Our data provide a valuable resource to study adult neurogenesis and a proof of principle for the power of single-cell RNA sequencing to elucidate neural cell-type-specific alterations in loss-of-function models.<br />
|mesh-terms=* Aging<br />
* Animals<br />
* Cell Lineage<br />
* Cell Proliferation<br />
* Dentate Gyrus<br />
* Gene Expression Regulation<br />
* Lateral Ventricles<br />
* Low Density Lipoprotein Receptor-Related Protein-2<br />
* Mice, Inbred C57BL<br />
* Models, Biological<br />
* Neural Stem Cells<br />
* Neurogenesis<br />
* RNA<br />
* RNA, Long Noncoding<br />
* Single-Cell Analysis<br />
* Stem Cell Niche<br />
* Transcriptome<br />
|keywords=* Drop-seq<br />
* LDL-receptor related protein 2<br />
* RNA velocity<br />
* adult neural stem cells<br />
* adult neurogenesis<br />
* neurogenic niche<br />
* single-cell RNA sequencing<br />
* subventricular zone<br />
|full-text-url=https://sci-hub.do/10.1016/j.celrep.2018.11.003<br />
}}</div>OdysseusBot