https://transhumanist.ru/index.php?action=history&feed=atom&title=LRP1B 2026-06-29T13:26:24Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=LRP1B&diff=5068&oldid=prev 2021-05-12T13:27:49Z

<p>Новая страница: «Low-density lipoprotein receptor-related protein 1B precursor (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) [LRPDIT] ==P...»</p> <p><b>Новая страница</b></p><div>Low-density lipoprotein receptor-related protein 1B precursor (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) [LRPDIT]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=A genome screen of successful aging without cognitive decline identifies [[LRP1B]] by haplotype analysis.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/19367585<br /> |abstract=Successful aging without cognitive decline (SA) is apparent in those who escape age-related illnesses, such as cardiovascular disease and dementia. To determine whether there are protective genotypes that increase the probability of successful cognitive aging, a genome-wide screen was conducted on subjects who were 85 years of older, had MMSE scores &gt;26, and had no major illnesses. SNP 500K microarrays were used. The data from the microarrays was analyzed versus that from Alzheimer&#039;s patients. Three SNPs in the gene for the low density lipoprotein receptor-related protein 1B ([[LRP1B]]) had significant P values, after Bonferroni correction. Additional SNPs were analyzed in this very large gene. Haplotypes in intron 18 were significant for successful aging versus Alzheimer&#039;s patients; those haplotypes were not significant when Alzheimer&#039;s patients versus CEPH controls were analyzed. These results suggest that haplotypes in the gene [[LRP1B]] are significant/protective for successful aging without cognitive decline.<br /> |mesh-terms=* Aging<br /> * Alzheimer Disease<br /> * Cognition<br /> * Genome<br /> * Haplotypes<br /> * Humans<br /> * Oligonucleotide Array Sequence Analysis<br /> * Polymorphism, Single Nucleotide<br /> * Receptors, LDL<br /> <br /> |full-text-url=https://sci-hub.do/10.1002/ajmg.b.30963<br /> }}</div>

OdysseusBot