https://transhumanist.ru/index.php?action=history&feed=atom&title=LGR4 2026-06-11T01:30:23Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=LGR4&diff=5257&oldid=prev 2021-05-12T13:36:17Z

<p>Новая страница: «Leucine-rich repeat-containing G-protein coupled receptor 4 precursor (G-protein coupled receptor 48) [GPR48] ==Publications== {{medline-entry |title=Conditiona...»</p> <p><b>Новая страница</b></p><div>Leucine-rich repeat-containing G-protein coupled receptor 4 precursor (G-protein coupled receptor 48) [GPR48]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Conditional knockout of Lgr4 leads to impaired ductal elongation and branching morphogenesis in mouse mammary glands.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21791950<br /> |abstract=We have analyzed the function of [[LGR4]] in the development of various mouse epithelial tissues. Here we first report the retarded invasion of mammary ducts into the fat pad observed in Lgr4(K5 KO) mice at 4 weeks, compared with that of age-matched Lgr4(K5 ctrl). Furthermore, we demonstrate a significant decrease in mammary ductal branching in Lgr4(K5 KO) at several stages (4, 6 and 8 weeks). On the other hand, immunohistochemical analysis of the mammary gland of Lgr4(K5 KO) using anti-αSMA, anti-K18 and anti-laminin antibodies showed structures similar to those of Lgr4(K5 ctrl) mammary glands. In addition, we did not detect significant differences in the expression of ERα, which was suggested to be a downstream molecule of [[LGR4]], and Lgr4(K5 KO) showed no retarded invasion in the response to 17β-estradiol administration. Furthermore, the phosphorylated form of Smad1/5/8 was normally detected in the mammary gland of Lgr4(K5 KO).<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Epithelial Cells<br /> * Estrogen Receptor alpha<br /> * Female<br /> * Mammary Glands, Animal<br /> * Mice<br /> * Mice, Knockout<br /> * Morphogenesis<br /> * Ovariectomy<br /> * Receptors, G-Protein-Coupled<br /> * Reverse Transcriptase Polymerase Chain Reaction<br /> <br /> |full-text-url=https://sci-hub.do/10.1159/000329476<br /> }}</div>

OdysseusBot