https://transhumanist.ru/index.php?action=history&feed=atom&title=LGI3 2026-11-08T23:41:00Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=LGI3&diff=5512&oldid=prev 2021-05-12T13:47:36Z

<p>Новая страница: «Leucine-rich repeat LGI family member 3 precursor (LGI1-like protein 4) (Leucine-rich glioma-inactivated protein 3) [LGIL4] [UNQ8190/PRO23199] ==Publications==...»</p> <p><b>Новая страница</b></p><div>Leucine-rich repeat LGI family member 3 precursor (LGI1-like protein 4) (Leucine-rich glioma-inactivated protein 3) [LGIL4] [UNQ8190/PRO23199]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Immunohistochemical and biochemical analyses of [[LGI3]] in monkey brain: [[LGI3]] accumulates in aged monkey brains.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/17786549<br /> |abstract=Leucine-rich glioma inactivated (LGI) 3 encodes a leucine-rich repeat protein. The precise function of [[LGI3]], however, remains unknown. We have previously shown that amyloid-beta peptide (Abeta) upregulates [[LGI3]] and that Abeta and [[LGI3]] colocalize on plasma membranes of cultured rat astrocytes. In the present study, we performed immunohistochemical and biochemical analyses of [[LGI3]] using various aged monkey brains. Immunohistochemistry showed that [[LGI3]] was present in almost all neural cells and mainly localized at plasma membranes and nuclei. In aged monkey brains, we found that [[LGI3]] accumulated on or near the plasma membranes of neurons, and colocalized with endocytosis-associated proteins and lipid raft markers. Double immunohistochemistry also showed that [[LGI3]] colocalized with Abeta in astrocytes of aged brains. Moreover, Western blot analyses revealed that [[LGI3]] may be cleaved in brain. Additionally, in aged monkeys [[LGI3]] accumulated in microsomal and nuclear brain fractions.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Blotting, Western<br /> * Brain<br /> * Cell Nucleus<br /> * Immunohistochemistry<br /> * Macaca fascicularis<br /> * Microsomes<br /> * Models, Biological<br /> * Protein Processing, Post-Translational<br /> * Proteins<br /> <br /> |full-text-url=https://sci-hub.do/10.1007/s10571-007-9205-6<br /> }}</div>

OdysseusBot