https://transhumanist.ru/index.php?action=history&feed=atom&title=KLF2KLF2 - История изменений2026-05-16T02:48:15ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=KLF2&diff=4158&oldid=prevOdysseusBot: Новая страница: «Krueppel-like factor 2 (Lung krueppel-like factor) [LKLF] ==Publications== {{medline-entry |title=KLF2 induces the senescence of pancreatic cancer cells by...»2021-04-29T19:03:38Z<p>Новая страница: «Krueppel-like factor 2 (Lung krueppel-like factor) [LKLF] ==Publications== {{medline-entry |title=<a href="/KLF2" title="KLF2">KLF2</a> induces the senescence of pancreatic cancer cells by...»</p>
<p><b>Новая страница</b></p><div>Krueppel-like factor 2 (Lung krueppel-like factor) [LKLF]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=[[KLF2]] induces the senescence of pancreatic cancer cells by cooperating with [[FOXO4]] to upregulate p21.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31866399<br />
|abstract=Pancreatic cancer is one of the most common malignancies in the world. Senescence is frequently observed in the progression of pancreatic cancer. In a previous study, we showed that [[KLF2]] inhibited the growth and migration of pancreatic cancer. However, the mechanisms are not fully understood. In this study, we showed that overexpression of [[KLF2]] induced the senescence of pancreatic cancer cells and inhibited tumorigenesis, and knockdown of [[KLF2]] inhibited senescence and p21 expression. In the molecular mechanism study, [[KLF2]] was found to interact with [[FOXO4]] and cooperated with [[FOXO4]] to induce the expression of p21. Downregulation of p21 and [[FOXO4]] impaired the induction of senescence by [[KLF2]]. Overall, this study revealed the functions and mechanisms of [[KLF2]] in senescence and provided a novel explanation for the suppressive roles of [[KLF2]] in pancreatic cancer.<br />
|mesh-terms=* Animals<br />
* Carcinogenesis<br />
* Cell Cycle Proteins<br />
* Cell Line<br />
* Cells, Cultured<br />
* Cellular Senescence<br />
* Cyclin-Dependent Kinase Inhibitor p21<br />
* Forkhead Transcription Factors<br />
* Kruppel-Like Transcription Factors<br />
* Male<br />
* Mice<br />
* Mice, Nude<br />
* Pancreatic Neoplasms<br />
* Protein Binding<br />
* Up-Regulation<br />
|keywords=* FOXO4<br />
* KLF2<br />
* Pancreatic cancer<br />
* Senescence<br />
|full-text-url=https://sci-hub.do/10.1016/j.yexcr.2019.111784<br />
}}</div>OdysseusBot