https://transhumanist.ru/index.php?action=history&feed=atom&title=KLC1KLC1 - История изменений2026-05-16T04:51:03ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=KLC1&diff=5245&oldid=prevOdysseusBot: Новая страница: «Kinesin light chain 1 (KLC 1) [KLC] [KNS2] ==Publications== {{medline-entry |title=Variability in the kinesin light chain 1 gene may influence risk of age-relat...»2021-05-12T13:35:47Z<p>Новая страница: «Kinesin light chain 1 (KLC 1) [KLC] [KNS2] ==Publications== {{medline-entry |title=Variability in the kinesin light chain 1 gene may influence risk of age-relat...»</p>
<p><b>Новая страница</b></p><div>Kinesin light chain 1 (KLC 1) [KLC] [KNS2]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Variability in the kinesin light chain 1 gene may influence risk of age-related cataract.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/17653041<br />
|abstract=Kinesin-mediated cargo vesicle transport is fundamental to the maintenance of a proper lens fiber structure, which is essential for the transparency of the lens. Here, we test the hypothesis that the rs8702 polymorphism in the kinesin light chain 1 gene ([[KLC1]]), previously linked to Alzheimer disease (AD), may play a role in cataractogenesis. Patients with nuclear (n=76), cortical (n=154), posterior subcapsular (n=117), and mixed (n=148) cataract as well as 183 controls were analyzed for the [[KLC1]] rs8702 polymorphism using the dynamic allele-specific hybridization (DASH) technique. The GG genotype of rs8702 was significantly over-represented among cataract patients as compared to controls (63% versus 52%, respectively, p=0.008) and associated with an age-adjusted odds ratio for cataract development of 1.61 (95% confidence interval 1.12-2.31). This association was not confined to any particular cataract type. The [[KLC1]] gene may be a novel susceptibility gene for age-related cataract.<br />
|mesh-terms=* Adult<br />
* Aged<br />
* Aged, 80 and over<br />
* Aging<br />
* Alleles<br />
* Cataract<br />
* Female<br />
* Gene Frequency<br />
* Genetic Predisposition to Disease<br />
* Genotype<br />
* Humans<br />
* Logistic Models<br />
* Male<br />
* Microtubule-Associated Proteins<br />
* Middle Aged<br />
* Nucleic Acid Hybridization<br />
* Odds Ratio<br />
* Polymorphism, Genetic<br />
* Smoking<br />
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|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776535<br />
}}</div>OdysseusBot