https://transhumanist.ru/index.php?action=history&feed=atom&title=KDR 2026-08-23T12:31:24Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=KDR&diff=4376&oldid=prev 2021-04-29T19:14:57Z

<p>Новая страница: «Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyro...»</p> <p><b>Новая страница</b></p><div>Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD309 antigen) [FLK1] [VEGFR2]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Regulation of endothelial progenitor cell differentiation and function by dimethylarginine dimethylaminohydrolase 2 in an asymmetric dimethylarginine-independent manner.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24764313<br /> |abstract=Endothelial progenitor cells (EPCs) are involved in the repair of vessels and angiogenesis and are useful in the treatment of ischemic diseases. The dimethylarginine dimethylaminohydrolase (DDAH)/asymmetric dimethylarginine (ADMA) pathway is regulated by silent information regulator 1 ([[SIRT1]]), leading to the senescence of endothelial cells (ECs). Here, we demonstrated that peripheral blood EPCs predominantly expressed [[DDAH2]] that increased with EPC differentiation. EPC senescence and dysfunction were induced on interruption of [[DDAH2]] expression, whereas the mRNA expression of vascular endothelial growth factor (VEGF) and kinase-domain insert containing receptor ([[KDR]]) were downregulated. Moreover, [[SIRT1]] expression increased with EPC differentiation. Interruption of [[SIRT1]] inhibited [[DDAH2]], VEGF, and [[KDR]] expression, but had no effect on the level of ADMA. From our data, we concluded that [[DDAH2]] is involved in the differentiation of EPCs and regulates the senescence and function of EPCs through the VEGF/[[KDR]] pathway by activation of [[SIRT1]]. <br /> |mesh-terms=* Amidohydrolases<br /> * Arginine<br /> * Cell Differentiation<br /> * Cells, Cultured<br /> * Cellular Senescence<br /> * Endothelial Progenitor Cells<br /> * Humans<br /> * RNA Interference<br /> * RNA, Messenger<br /> * RNA, Small Interfering<br /> * Sirtuin 1<br /> * Vascular Endothelial Growth Factor A<br /> * Vascular Endothelial Growth Factor Receptor-2<br /> |keywords=* SIRT1<br /> * dimethylarginine dimethylaminohydrolase<br /> * endothelial progenitor cells<br /> * senescence<br /> |full-text-url=https://sci-hub.do/10.1002/cbin.10288<br /> }}</div>

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