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Interleukin-31 receptor subunit alpha precursor (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17) [CRL3] [GPL] [UNQ6368/PRO21073/PRO21384]

==Publications==

{{medline-entry
|title=Complete overlap of interleukin-31 receptor A and oncostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16926070
|abstract=Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. Recent studies have shown that IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor ([[OSM]]Rbeta). However, little is known about the target cells of IL-31 because it remains unclear which types of cells express IL-31RA. In our previous reports, we demonstrated that [[OSM]]Rbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs). In the present study, we investigated the IL-31RA expression in the adult and developing DRGs. From a northern blot analysis and in situ hybridization histochemistry, IL-31RA mRNA was found to be expressed in the adult DRGs. According to reverse-transcriptase polymerase chain reaction, IL-31RA mRNA was detected in the DRGs and trigeminal ganglia, while no expression of IL-31RA mRNA was observed in the CNS. Double immunofluorescence staining revealed IL-31RA to be expressed in a subset of small-sized neurons, all of which colocalized with [[OSM]]Rbeta. In addition, the expression of IL-31 RA was detected in afferent fibers in the spinal cord and the dermis of the skin. We also found that the developmental expression pattern of IL-31RA was different from that of [[OSM]]Rbeta; [[IL31RA]]-positive neurons in DRGs first appeared at postnatal day (PN) 10 and reached the adult level at PN14, whereas [[OSM]]Rbeta-positive neurons were observed at PN0 for the first time. We previously demonstrated [[OSM]]Rbeta-expressing neurons to decrease, however, they were not found to disappear in oncostatin M ([[OSM]]) -deficient mice. These findings suggest that IL-31 and [[OSM]] may thus have redundant functions in the development of [[OSM]]Rbeta-expressing neurons.
|mesh-terms=* Aging
* Animals
* Animals, Newborn
* Fluorescent Antibody Technique
* Ganglia, Spinal
* Gene Expression Regulation, Developmental
* Male
* Mice
* Mice, Inbred C57BL
* Neurons, Afferent
* Nociceptors
* Oncostatin M Receptor beta Subunit
* RNA, Messenger
* Receptors, Interleukin
* Skin
* Trigeminal Ganglion

|full-text-url=https://sci-hub.do/10.1016/j.neuroscience.2006.07.009
}}

IL31RA - История изменений

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