https://transhumanist.ru/index.php?action=history&feed=atom&title=HSPB8HSPB8 - История изменений2026-04-13T10:09:16ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=HSPB8&diff=5654&oldid=prevOdysseusBot: Новая страница: «Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Protein kinase H11) (Small stress protein-like protein HSP22) [CRYAC] [E...»2021-05-12T13:53:56Z<p>Новая страница: «Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Protein kinase H11) (Small stress protein-like protein HSP22) [CRYAC] [E...»</p>
<p><b>Новая страница</b></p><div>Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Protein kinase H11) (Small stress protein-like protein HSP22) [CRYAC] [E2IG1] [HSP22] [PP1629]<br />
<br />
==Publications==<br />
<br />
{{medline-entry<br />
|title=[[BAG3]] and friends: co-chaperones in selective autophagy during aging and disease.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21681022<br />
|abstract=There is a reciprocal change in the expression of two members of the BAG (Bcl-2-associated athanogen) family, [[BAG1]] and [[BAG3]], during cellular aging and under acute stress ("[[BAG1]]-[[BAG3]]-switch"). [[BAG3]] was recently described as a mediator of a novel macroautophagy pathway that uses the specificity of heat shock protein 70 (HSP70) to misfolded proteins and also involves other protein partners, such as [[HSPB8]]. Also crucial for induction and execution of autophagy are sequestosome-1/p62 (SQSTM1/p62) and LC3, an autophagosome-associated protein. In this novel pathway, [[BAG3]] mediates the targeting and transport of degradation-prone substrates into aggresomes via the microtubule-motor dynein. Interestingly, aggresome-targeting by [[BAG3]] does not depend on substrate ubiquitination and is, therefore, involved in the clearance of misfolded proteins that are not ubiquitinated.<br />
|mesh-terms=* Adaptation, Physiological<br />
* Adaptor Proteins, Signal Transducing<br />
* Aging<br />
* Animals<br />
* Autophagy<br />
* DNA-Binding Proteins<br />
* Disease<br />
* Dyneins<br />
* Models, Biological<br />
* Molecular Chaperones<br />
* Proteasome Endopeptidase Complex<br />
* Transcription Factors<br />
* Ubiquitination<br />
<br />
|full-text-url=https://sci-hub.do/10.4161/auto.7.7.15844<br />
}}</div>OdysseusBot