https://transhumanist.ru/index.php?action=history&feed=atom&title=HSPA14HSPA14 - История изменений2026-06-11T12:19:36ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=HSPA14&diff=5601&oldid=prevOdysseusBot: Новая страница: «Heat shock 70 kDa protein 14 (HSP70-like protein 1) (Heat shock protein HSP60) [HSP60] [HSP70L1] ==Publications== {{medline-entry |title=Evidence from case-cont...»2021-05-12T13:51:40Z<p>Новая страница: «Heat shock 70 kDa protein 14 (HSP70-like protein 1) (Heat shock protein HSP60) [HSP60] [HSP70L1] ==Publications== {{medline-entry |title=Evidence from case-cont...»</p>
<p><b>Новая страница</b></p><div>Heat shock 70 kDa protein 14 (HSP70-like protein 1) (Heat shock protein HSP60) [HSP60] [HSP70L1]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Evidence from case-control and longitudinal studies supports associations of genetic variation in [[APOE]], [[CETP]], and [[IL6]] with human longevity.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22234866<br />
|abstract=In this study, we investigated 102 single-nucleotide polymorphisms (SNPs) covering the common genetic variation in 16 genes recurrently regarded as candidates for human longevity: [[APOE]]; ACE; [[CETP]]; HFE; [[IL6]]; [[IL6]]R; MTHFR; TGFB1; APOA4; APOC3; SIRTs 1, 3, 6; and HSPAs 1A, 1L, 14. In a case-control study of 1,089 oldest-old (ages 92-93) and 736 middle-aged Danes, the minor allele frequency ([[MAF]]) of rs769449 ([[APOE]]) was significantly decreased in the oldest-old, while the [[MAF]] of rs9923854 ([[CETP]]) was significantly enriched. These effects were supported when investigating 1,613 oldest-old (ages 95-110) and 1,104 middle-aged Germans. rs769449 was in modest linkage equilibrium (R (2)=0.55) with rs429358 of the [[APOE]]-ε4 haplotype and adjusting for rs429358 eliminated the association of rs769449, indicating that the association likely reflects the well-known effect of rs429358. Gene-based analysis confirmed the effects of variation in [[APOE]] and [[CETP]] and furthermore pointed to [[HSPA14]] as a longevity gene. In a longitudinal study with 11 years of follow-up on survival in the oldest-old Danes, only one SNP, rs2069827 ([[IL6]]), was borderline significantly associated with survival from age 92 (P-corrected=0.064). This advantageous effect of the minor allele was supported when investigating a Dutch longitudinal cohort (N=563) of oldest-old (age 85 ). Since rs2069827 was located in a putative transcription factor binding site, quantitative RNA expression studies were conducted. However, no difference in [[IL6]] expression was observed between rs2069827 genotype groups. In conclusion, we here support and expand the evidence suggesting that genetic variation in [[APOE]], [[CETP]], and [[IL6]], and possible [[HSPA14]], is associated with human longevity.<br />
|mesh-terms=* Aged, 80 and over<br />
* Alleles<br />
* Apolipoproteins E<br />
* Case-Control Studies<br />
* Cholesterol Ester Transfer Proteins<br />
* Denmark<br />
* Female<br />
* Gene Frequency<br />
* Genetic Variation<br />
* Genotype<br />
* Germany<br />
* Haplotypes<br />
* Humans<br />
* Interleukin-6<br />
* Linear Models<br />
* Longevity<br />
* Longitudinal Studies<br />
* Male<br />
* Middle Aged<br />
* Netherlands<br />
* Polymorphism, Single Nucleotide<br />
* Registries<br />
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|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592963<br />
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