https://transhumanist.ru/index.php?action=history&feed=atom&title=HSD11B1 2026-06-14T15:47:00Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=HSD11B1&diff=5603&oldid=prev 2021-05-12T13:51:46Z

<p>Новая страница: «Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-beta-hydroxysteroid dehydrogenase 1) (11-DH) (11-beta-HSD1) (Short chain dehydrogenase/reductase...»</p> <p><b>Новая страница</b></p><div>Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-beta-hydroxysteroid dehydrogenase 1) (11-DH) (11-beta-HSD1) (Short chain dehydrogenase/reductase family 26C member 1) [HSD11] [HSD11L] [SDR26C1]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 ([[HSD11B1]]) and lifetime cognitive change.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16236446<br /> |abstract=A rare polymorphism in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 ([[HSD11B1]]: rs846911-C/A) has been associated with an increased risk of Alzheimer&#039;s disease. We tested the hypothesis that this and 2 other [[HSD11B1]] polymorphisms (rs12086634-G/T and rs846910-A/G) were associated with lifetime cognitive change in humans. Subjects were 194 participants of the Scottish Mental Survey of 1932 who took the same well-validated mental test at age 11 and age 79. The subjects represented the highest and lowest quintiles with respect to cognitive decline between ages 11 and 79. Despite having non-significantly different IQs at age 11, by age 79 the groups had mean (S.D.) IQs of 80.3 (14.1) and 109.6 (9.1), respectively (p&lt;.001). The polymorphism rs846911-C/A was absent from both groups. There were no significant differences in the frequency of polymorphisms of rs12086634-G/T (p=.91) and rs846910-A/G (p=.90) between the groups. We conclude that these variants in [[HSD11B1]] are not significant contributors to the range of cognitive ageing examined here.<br /> |mesh-terms=* 11-beta-Hydroxysteroid Dehydrogenase Type 1<br /> * Aged<br /> * Aging<br /> * Cognition<br /> * Cohort Studies<br /> * Demography<br /> * Female<br /> * Humans<br /> * Male<br /> * Polymorphism, Genetic<br /> * Time Factors<br /> <br /> |full-text-url=https://sci-hub.do/10.1016/j.neulet.2005.09.047<br /> }}</div>

OdysseusBot