https://transhumanist.ru/index.php?action=history&feed=atom&title=HPGDSHPGDS - История изменений2026-11-08T11:15:11ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=HPGDS&diff=5085&oldid=prevOdysseusBot: Новая страница: «Hematopoietic prostaglandin D synthase (EC 5.3.99.2) (H-PGDS) (GST class-sigma) (Glutathione S-transferase) (EC 2.5.1.18) (Glutathione-dependent PGD synthase) (Gl...»2021-05-12T13:28:32Z<p>Новая страница: «Hematopoietic prostaglandin D synthase (EC 5.3.99.2) (H-PGDS) (GST class-sigma) (Glutathione S-transferase) (EC 2.5.1.18) (Glutathione-dependent PGD synthase) (Gl...»</p>
<p><b>Новая страница</b></p><div>Hematopoietic prostaglandin D synthase (EC 5.3.99.2) (H-PGDS) (GST class-sigma) (Glutathione S-transferase) (EC 2.5.1.18) (Glutathione-dependent PGD synthase) (Glutathione-requiring prostaglandin D synthase) (Prostaglandin-H2 D-isomerase) [GSTS] [PGDS] [PTGDS2]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Hematopoietic prostaglandin D synthase is expressed in microglia in the developing postnatal mouse brain.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/12673832<br />
|abstract=Hematopoietic prostaglandin D synthase ([[HPGDS]]) is a PGD(2)-synthesizing enzyme and is expressed in antigen-presenting cells, mast cells, and other immunocompetent cells. We here report the [[HPGDS]] expression in microglia and the migration pathway of microglia in the developing mouse brain as detected by [[HPGDS]] immunohistochemistry. Expression of [[HPGDS]] mRNA peaked at postnatal day (PND) 10, decreased gradually thereafter, and reached a plateau at PND 20. The mRNAs for target molecules of PGD(2), i.e., DP receptor (DPR) and CRTH2 receptor, showed developmental profiles overlapped to that of [[HPGDS]]. Most of the [[HPGDS]]( ) cells at PND 10 had morphological characteristics of ameboid microglia and gave positive immunostaining with microglia-specific markers such as RCA-1, F4/80, or ER-MP12. These specific markers became less detectable later on, but [[HPGDS]] was still expressed even in resting microglia. Thus, [[HPGDS]] is a useful marker for investigation of microglial development. Spaciotemporal evaluation of microglial development and migration with [[HPGDS]] immunostaining revealed the following three major possible migration pathways of microglia in the postnatal brain: from the lateral ventricle via subventricular zones to brain parenchyma; from the leptomeninges around the cerebellopontine angle to the cerebellar white matter; and from the overlying leptomeninges to the hippocampus, basal forebrain, and brainstem.<br />
|mesh-terms=* Aging<br />
* Animals<br />
* Animals, Newborn<br />
* Antigens, Differentiation<br />
* Biomarkers<br />
* Brain<br />
* Cell Differentiation<br />
* Cell Movement<br />
* Cell Size<br />
* Female<br />
* Gene Expression Regulation, Developmental<br />
* Immunohistochemistry<br />
* Intramolecular Oxidoreductases<br />
* Lipocalins<br />
* Male<br />
* Mice<br />
* Mice, Inbred C57BL<br />
* Mice, Knockout<br />
* Microglia<br />
* Platelet Endothelial Cell Adhesion Molecule-1<br />
* Prostaglandin D2<br />
* RNA, Messenger<br />
* Receptors, Cytoplasmic and Nuclear<br />
* Receptors, Immunologic<br />
* Receptors, Prostaglandin<br />
* Transcription Factors<br />
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|full-text-url=https://sci-hub.do/10.1002/glia.10183<br />
}}</div>OdysseusBot