https://transhumanist.ru/index.php?action=history&feed=atom&title=HMGCS2HMGCS2 - История изменений2026-04-06T15:23:23ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=HMGCS2&diff=3929&oldid=prevOdysseusBot: Новая страница: «Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor (EC 2.3.3.10) (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase) ==Publications== {...»2021-04-29T18:52:11Z<p>Новая страница: «Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor (EC 2.3.3.10) (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase) ==Publications== {...»</p>
<p><b>Новая страница</b></p><div>Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor (EC 2.3.3.10) (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase)<br />
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==Publications==<br />
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{{medline-entry<br />
|title=The aged testis. A good model to find proteins involved in age-related changes of testis by proteomic analysis.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24597284<br />
|abstract=To explore associated proteins involved in age-related changes of the testis and better understand the roles of these proteins in the human testis. We used two-dimensional polyacrylamide gel electrophoresis (2-DE) and matrix-assisted laser desorption/ionization time-of-flight mass spec trometry analysis to identify differentially expressed proteins between the aged and the normal control groups. The L-lactate dehydrogenase C chain ([[LDHC]]) protein, a previous testis-specific protein, was found to be downregulated in the aged testis and was further tested with western blot and immunohistochemical analysis to verify the result of the [[LDHC]] protein in 2-DE. Twelve differentially expressed proteins were identified. Among those proteins, 3 were upregulated and 9 were downregulated in the aged group. The results of western blot and immunohistochemical analysis confirmed the expression of [[LDHC]] downregulation in the aged testis. Some proteins identified had little well-known function in the human testis, as follows: [[AKR7A3]], [[FDXR]], [[PGAM1]], SEPT2 and [[HMGCS2]]. Our results imply that the aged testis can be a good model to find associated proteins involved in age-related changes of the testis. It can be useful to understand the roles of those proteins in the testis.<br />
|mesh-terms=* Aged<br />
* Aging<br />
* Down-Regulation<br />
* Electrophoresis, Gel, Two-Dimensional<br />
* Humans<br />
* Immunohistochemistry<br />
* Isoenzymes<br />
* L-Lactate Dehydrogenase<br />
* Male<br />
* Middle Aged<br />
* Proteins<br />
* Proteomics<br />
* Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization<br />
* Testis<br />
* Young Adult<br />
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}}</div>OdysseusBot