https://transhumanist.ru/index.php?action=history&feed=atom&title=HLA-DQB1HLA-DQB1 - История изменений2026-04-10T22:26:42ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=HLA-DQB1&diff=4721&oldid=prevOdysseusBot: Новая страница: «HLA class II histocompatibility antigen, DQ beta 1 chain precursor (MHC class II antigen DQB1) [HLA-DQB] ==Publications== {{medline-entry |title=Identification...»2021-04-29T19:31:51Z<p>Новая страница: «HLA class II histocompatibility antigen, DQ beta 1 chain precursor (MHC class II antigen DQB1) [HLA-DQB] ==Publications== {{medline-entry |title=Identification...»</p>
<p><b>Новая страница</b></p><div>HLA class II histocompatibility antigen, DQ beta 1 chain precursor (MHC class II antigen DQB1) [HLA-DQB]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Identification of new genetic variants of [[HLA-DQB1]] associated with human longevity and lipid homeostasis-a cross-sectional study in a Chinese population.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29129831<br />
|abstract=Healthy longevity has been an unremitting pursuit of human, but its genetic and the environment causes are still unclear. As longevity population is a good healthy aging model for understanding how the body begin aging and the process of aging, and plasma lipids metabolism and balance is a very important to life maintain and physiologic functional turnover. It is important to explore how the effect of genetic variants associated long-life individuals on lipids metabolism and balance. Therefore, we developed a comparative study based population which contains 2816 longevity and 2819 control. Through whole-exome sequencing and sanger sequencing genotypes, we identified four new single nucleotide polymorphisms of [[HLA-DQB1]](major histocompatibility complex, class II, DQ beta 1), rs41542812 rs1049107 rs1049100 rs3891176([i]P [/i]=0.048-2.811×10 for allele frequencies), associated with longevity in Chinese Longevity Cohort. Further, by analysis of the longevity-variants linked to blood lipids, we identified [[HLA-DQB1]] rs1049107, T-carriers ([i]P [/i]=0.006, OR: 11.277; [i]P [/i]=9.095×10 , OR: 0.025; [i]P [/i]=0.047, OR: 1.901) and [[HLA-DQB1]] rs1049100, T-carriers ([i]P [/i]=1.799×10-6, OR: 0.028) associated with lipid homeostasis in long lived individuals. Our finding showed that longevity and lipid homeostasis were associated with [[HLA-DQB1]] and suggested that immune gene variants could act on both new function of maintaining the homeostasis and anti-aging in longevity.<br />
|mesh-terms=* Adult<br />
* Aged, 80 and over<br />
* Asian Continental Ancestry Group<br />
* Case-Control Studies<br />
* Chi-Square Distribution<br />
* China<br />
* Computational Biology<br />
* Cross-Sectional Studies<br />
* Databases, Genetic<br />
* Female<br />
* Gene Frequency<br />
* Genetic Association Studies<br />
* HLA-DQ beta-Chains<br />
* Haplotypes<br />
* Health Status<br />
* Homeostasis<br />
* Humans<br />
* Lipid Metabolism<br />
* Lipids<br />
* Longevity<br />
* Male<br />
* Middle Aged<br />
* Odds Ratio<br />
* Phenotype<br />
* Polymorphism, Single Nucleotide<br />
|keywords=* Chinese population<br />
* HLA-DQB1<br />
* human longevity<br />
* lipid phenotypes<br />
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723689<br />
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{{medline-entry<br />
|title=[Clinical and genetic characteristics of long-livers in Moscow region].<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24640693<br />
|abstract=In Moscow region long-livers we have studied distribution of [[LPL]], [[CETP]], [[APOE]], [[F2]], [[F5]], [[F7]], F13, [[FGB]], [[ITGA2]], [[ITGB3]], PAI-1, [[MTHFR]], [[MTRR]], [[HLA-DRB1]], [[HLA-DQA1]], [[HLA-DQB1]] genes polymorphisms, associated with predisposition to age pathology. Long-livers are characterized by favorable course of cardiovascular diseases accompanied by certain genetic factors. We have established that genotype H-H- of [[LPL]], allele epsilon2 of [[APOE]], genotype CC of [[MTHFR]] (677C > T), genotype TC of [[ITGB3]], genotype GA of [[FGB]], [[HLA-DRB1]]*11 positively correlate with longevity.<br />
|mesh-terms=* Aged<br />
* Aged, 80 and over<br />
* Alleles<br />
* Cardiovascular Diseases<br />
* Female<br />
* Gene Frequency<br />
* Genetic Markers<br />
* Genetic Predisposition to Disease<br />
* Genotype<br />
* Humans<br />
* Longevity<br />
* Male<br />
* Moscow<br />
* Polymorphism, Genetic<br />
* Prevalence<br />
* Urban Population<br />
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