https://transhumanist.ru/index.php?action=history&feed=atom&title=HDGFHDGF - История изменений2026-06-17T00:35:52ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=HDGF&diff=5267&oldid=prevOdysseusBot: Новая страница: «Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) [HMG1L2] ==Publications== {{medline-entry |title=Identification, cloning,...»2021-05-12T13:36:42Z<p>Новая страница: «Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) [HMG1L2] ==Publications== {{medline-entry |title=Identification, cloning,...»</p>
<p><b>Новая страница</b></p><div>Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) [HMG1L2]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Identification, cloning, and developmental expression of hepatoma-derived growth factor in the developing rat heart.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/11747079<br />
|abstract=Hepatoma derived growth factor ([[HDGF]]) was identified as a developmentally regulated cardiac gene by mRNA differential display using 12-day rat fetal conotruncus vs. newborn aorta. The full-length rat [[HDGF]] cDNA was cloned from a rat fetal heart cDNA library and found to be 94 and 88% homologous to the mouse and human sequence, respectively. The rat sequence, like the human and mouse, contains a highly conserved amino portion and putative bipartite nuclear localization sequence. By Northern analysis, [[HDGF]] is highly expressed in the fetal conotruncus, heart, kidney, brain, and gut. By immunocytochemistry, [[HDGF]] was first detected only in atrial myocytes, hind gut epithelia, and notochord of the E10 rat with a nuclear expression pattern. By E12, expression had broadened to include the ventricular myocytes, endocardial cells, and cells of the ventricular outflow tract. [[HDGF]] is unique in that it is the first described nuclear targeted growth factor in the developing heart. The early expression of [[HDGF]] in embryonic heart and fetal gut suggests that [[HDGF]] may play a role in cardiovascular growth and differentiation.<br />
|mesh-terms=* Aging<br />
* Amino Acid Sequence<br />
* Animals<br />
* Base Sequence<br />
* Cardiovascular System<br />
* Cloning, Molecular<br />
* Embryo, Mammalian<br />
* Embryonic and Fetal Development<br />
* Gene Expression Profiling<br />
* Gene Expression Regulation, Developmental<br />
* Growth Substances<br />
* Heart<br />
* Intercellular Signaling Peptides and Proteins<br />
* Molecular Sequence Data<br />
* Myocardium<br />
* Rats<br />
* Rats, Sprague-Dawley<br />
* Sequence Homology, Amino Acid<br />
* Tissue Distribution<br />
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|full-text-url=https://sci-hub.do/10.1002/dvdy.1204<br />
}}</div>OdysseusBot