https://transhumanist.ru/index.php?action=history&feed=atom&title=HBB 2026-07-04T19:11:11Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=HBB&diff=5762&oldid=prev 2021-05-12T13:58:40Z

<p>Новая страница: «Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Contains: LVV-hemorphin-7; Spinorphin] ==Publications== {{medline-entry |title=Induction of immun...»</p> <p><b>Новая страница</b></p><div>Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Contains: LVV-hemorphin-7; Spinorphin]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Induction of immunotoxicity in mice by polyhalogenated biphenyls.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/3092783<br /> |abstract=Acute administration of Aroclor-1254 (500 mg/kg) or 3,4,5,3&#039;,4&#039;,5&#039;-hexabromobiphenyl ([[HBB]]) (2-6 mg/kg) IP, profoundly inhibited the plaque forming response to subsequent challenge with sheep erythrocytes in Ah locus positive (C57Bl/6N or B6C3F1N) mice. These studies showed: the immunotoxicity results paralleled enzyme induction results insofar as [[HBB]] was approximately 100 times more potent than Aroclor 1254; neither Aroclor nor [[HBB]] treatment caused significant induction in the Ah locus negative DBA/2N mice; when B6C3F1 mice were challenged with sheep red blood cells (SRBC) 6 or 16 weeks post Aroclor 1254 treatment, substantial recovery of a PFC response was observed; when these compounds were administered to older (76-week-old) (B6C3F1 mice, severe depression of a PFC response was observed. In contrast to its profound depression of a PFC response, Aroclor-1254 (up to 1250 mg/kg) caused slight increases in lymphocyte proliferation induced by either T or B cell mitogens. A single 500 mg/kg dose of Aroclor-1254 also suppressed the ability of recipient B6C3F1 animals to reject a challenge with either the syngenic fibrosarcoma (PYB6) or the gram negative pathogen (Listeria monocytogenes).<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Aroclors<br /> * Chlorodiphenyl (54% Chlorine)<br /> * Cyclophosphamide<br /> * Cytochrome P-450 Enzyme System<br /> * Dealkylation<br /> * Fibrosarcoma<br /> * Hemolytic Plaque Technique<br /> * Immunity<br /> * Listeria monocytogenes<br /> * Lymphocyte Activation<br /> * Mice<br /> * Mice, Inbred C3H<br /> * Mice, Inbred C57BL<br /> * Mice, Inbred DBA<br /> * Polychlorinated Biphenyls<br /> <br /> |full-text-url=https://sci-hub.do/10.1007/BF00286726<br /> }}</div>

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