https://transhumanist.ru/index.php?action=history&feed=atom&title=GRK3 2026-06-23T21:23:19Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=GRK3&diff=5486&oldid=prev 2021-05-12T13:46:14Z

<p>Новая страница: «Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [ADRBK2] [BARK2] ==Publications== {{medline-entry |title=Alt...»</p> <p><b>Новая страница</b></p><div>Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [ADRBK2] [BARK2]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Alterations of epinephrine-induced gluconeogenesis in aging.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/19307753<br /> |abstract=The effects of glucagon and epinephrine on gluconeogenesis in young (4 month) and old (24 month) Fisher 344 rat hepatocytes were compared. In contrast to glucagon, which had a similar effect on gluconeogenesis in both young and old cells, epinephrine caused a smaller increase in gluconeogenesis in old rat hepatocytes than in young hepatocytes. beta2 adrenergic receptor (beta2-[[AR]]) expression slightly decreased in aged rat liver, and there were differences between young and old hepatocytes in their patterns of G protein coupled receptor kinases, which are involved in the activation of beta2-[[AR]] receptor signal desensitization. The major isoform of the kinase changed from [[GRK2]] to [[GRK3]] and the expression of beta-arrestin, which is recruited by the phosphorylated beta2-[[AR]] for internalization and degradation, increased in aged rat liver. [[GRK3]] overexpression also decreased the glucose output from young rat hepatocytes. We conclude that an age-associated reduction in epinephrine-induced gluconeogenesis occurs through the epinephrine receptor desensitizing system.<br /> |mesh-terms=* Adrenergic beta-2 Receptor Agonists<br /> * Adrenergic beta-Agonists<br /> * Aging<br /> * Animals<br /> * Epinephrine<br /> * G-Protein-Coupled Receptor Kinase 2<br /> * G-Protein-Coupled Receptor Kinase 3<br /> * Glucagon<br /> * Gluconeogenesis<br /> * Male<br /> * Models, Biological<br /> * Phosphorylation<br /> * Rats<br /> * Rats, Inbred F344<br /> * Receptors, Adrenergic, beta-2<br /> <br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701982<br /> }}</div>

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