https://transhumanist.ru/index.php?action=history&feed=atom&title=GPR139 2026-07-04T23:40:48Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=GPR139&diff=5710&oldid=prev 2021-05-12T13:56:22Z

<p>Новая страница: «Probable G-protein coupled receptor 139 (G(q)-coupled orphan receptor GPRg1) (G-protein-coupled receptor PGR3) [GPRG1] [PGR3] ==Publications== {{medline-entry |...»</p> <p><b>Новая страница</b></p><div>Probable G-protein coupled receptor 139 (G(q)-coupled orphan receptor GPRg1) (G-protein-coupled receptor PGR3) [GPRG1] [PGR3]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Characterisation and differential expression of two very closely related G-protein-coupled receptors, [[GPR139]] and [[GPR142]], in mouse tissue and during mouse development.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16378626<br /> |abstract=By searching the human and mouse genomic databases we found two G-protein-coupled receptors, [[GPR139]] and [[GPR142]], with characteristic motifs of the rhodopsin family of receptors. The gene for [[GPR139]] maps to chromosome 7F1 of mouse and 16p12.3 of human and that for [[GPR142]] to 11E2 of mouse and 17q25.1 of human. We isolated [[GPR139]] from a cDNA library of adult mouse brain and [[GPR142]] from a cDNA library of brains from 15-day-old mouse embryos. [[GPR139]] mRNA was predominantly expressed in specific areas of human and mouse brains, whereas [[GPR142]] mRNA showed a more ubiquitous expression both in the brain and in various peripheral glands and organs. A 50% identity and a 67% homology at the amino-acid level between the two receptors and only 20-25% identity with other G-protein-coupled receptors established them as a new subbranch within the phylogenetic tree and hints at a common or similar ligand(s). Preliminary results suggest that the cognate ligand is present in brain extracts and is, most likely, a small peptide. [[GPR139]] signal transduction in Chinese hamster ovary cells requires coupling to an inhibitory G-protein and is mediated by phospholipase C. Dimer formation may be necessary for proper function.<br /> |mesh-terms=* Aging<br /> * Amino Acid Sequence<br /> * Animals<br /> * Brain<br /> * Cloning, Molecular<br /> * Conserved Sequence<br /> * Embryonic Development<br /> * Gene Expression Regulation, Developmental<br /> * Humans<br /> * Mice<br /> * Molecular Sequence Data<br /> * Nerve Tissue Proteins<br /> * Organ Specificity<br /> * RNA, Messenger<br /> * Receptors, G-Protein-Coupled<br /> * Recombinant Proteins<br /> * Sequence Alignment<br /> * Sequence Homology, Amino Acid<br /> <br /> |full-text-url=https://sci-hub.do/10.1016/j.neuropharm.2005.11.003<br /> }}</div>

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