https://transhumanist.ru/index.php?action=history&feed=atom&title=GFRA2 2026-08-11T00:12:38Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=GFRA2&diff=5430&oldid=prev 2021-05-12T13:43:41Z

<p>Новая страница: «GDNF family receptor alpha-2 precursor (GDNF receptor alpha-2) (GDNFR-alpha-2) (GFR-alpha-2) (GDNF receptor beta) (GDNFR-beta) (Neurturin receptor alpha) (NRTNR-a...»</p> <p><b>Новая страница</b></p><div>GDNF family receptor alpha-2 precursor (GDNF receptor alpha-2) (GDNFR-alpha-2) (GFR-alpha-2) (GDNF receptor beta) (GDNFR-beta) (Neurturin receptor alpha) (NRTNR-alpha) (NTNR-alpha) (RET ligand 2) (TGF-beta-related neurotrophic factor receptor 2) [GDNFRB] [RETL2] [TRNR2]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Glial cell line-derived neurotrophic factor receptor alpha 2 ([[GFRA2]]) gene is associated with tardive dyskinesia.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/20369355<br /> |abstract=Tardive dyskinesia (TD) has a pharmacogenetic component in which the interaction of antipsychotic exposure with individual genetic variation mediates risk. The glial cell line-derived neurotrophic factor ([[GDNF]]) signalling pathway has been associated with neuroprotective effects in central dopaminergic neurons and spinal motor neurons. Clinical trials have also investigated whether [[GDNF]] may ameliorate Parkinson&#039;s disease symptoms. We tested whether variants in the [[GDNF]] receptor alpha 2 ([[GFRA2]]) gene could play a role in TD susceptibility evaluating 16 variants in 172 Caucasian schizophrenia subjects. We observed one significant allelic association (rs4739285, permuted p = 0.042) and two genotypic associations: rs4739285 under additive inheritance model and rs4739217 under dominant inheritance model (permuted p = 0.044). Moreover, carriers of the major alleles for both rs6587002 and rs4739217 presented significantly higher risk for TD (OR = 2.04, permuted p = 0.014), while subjects with the minor allele for rs4739217 and the major allele for rs6988470 were less likely to have TD (OR = 0.21, permuted p = 0.0007). Haplotype results indicate that the minor allele of the rs4739217 is a risk factor for TD (permuted allelic p = 0.074). Age was also a risk factor for TD in our sample (p = 0.0001). Taken together, our findings suggest that [[GFRA2]] genetic variants and age may play a role in TD susceptibility, but further work is required to confirm these findings.<br /> |mesh-terms=* Adult<br /> * Aging<br /> * Alleles<br /> * Antipsychotic Agents<br /> * Dyskinesia, Drug-Induced<br /> * Female<br /> * Genetic Predisposition to Disease<br /> * Genetic Variation<br /> * Genotype<br /> * Glial Cell Line-Derived Neurotrophic Factor Receptors<br /> * Haplotypes<br /> * Humans<br /> * Male<br /> * Middle Aged<br /> * Risk Factors<br /> * Schizophrenia<br /> <br /> |full-text-url=https://sci-hub.do/10.1007/s00213-010-1829-4<br /> }}</div>

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