https://transhumanist.ru/index.php?action=history&feed=atom&title=GDF7 2026-09-06T03:30:44Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=GDF7&diff=5444&oldid=prev 2021-05-12T13:44:16Z

<p>Новая страница: «Growth/differentiation factor 7 precursor (GDF-7) ==Publications== {{medline-entry |title=Growth/differentiation factor 7 is preferentially expressed in the pri...»</p> <p><b>Новая страница</b></p><div>Growth/differentiation factor 7 precursor (GDF-7)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Growth/differentiation factor 7 is preferentially expressed in the primary motor area of the monkey neocortex.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/11238730<br /> |abstract=We applied a differential display PCR technique to isolate molecules that are area-specific in expression in the primate neocortex, and found that growth/differentiation factor 7 ([[GDF7]]), a member of the bone morphogenetic protein (BMP)/transforming growth factor (TGF) beta super-family, is preferentially expressed in the primary motor area of African green monkeys (Cercopithecus aethiops). We proved that [[GDF7]] is 10 times more abundant in the motor cortex than in the visual cortex by northern blotting and quantitative RT-PCR. When we examined the neocortex of closely related rhesus monkeys (Macaca mulatta), [[GDF7]] was also most abundant in the motor cortex, although the regional difference was reduced to 3-fold. This differential expression pattern was observed in both newborn and infant rhesus monkeys. We found that several type I/II receptors of BMP, candidates of the receptors for [[GDF7]], are uniformly expressed in the mature neocortex. The unique expression pattern of [[GDF7]] suggests that it may play an active role in the motor area of the primate neocortex.<br /> |mesh-terms=* Aging<br /> * Amino Acid Sequence<br /> * Animals<br /> * Animals, Newborn<br /> * Bone Morphogenetic Proteins<br /> * Chlorocebus aethiops<br /> * Gene Expression Regulation, Developmental<br /> * Gene Library<br /> * Growth Substances<br /> * Macaca fascicularis<br /> * Macaca mulatta<br /> * Molecular Sequence Data<br /> * Motor Cortex<br /> * Neocortex<br /> * Organ Specificity<br /> * Polymerase Chain Reaction<br /> * RNA, Messenger<br /> * Recombinant Proteins<br /> * Sequence Alignment<br /> * Sequence Homology, Amino Acid<br /> * Transcription, Genetic<br /> * Transfection<br /> <br /> |full-text-url=https://sci-hub.do/10.1046/j.1471-4159.2001.00177.x<br /> }}</div>

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