https://transhumanist.ru/index.php?action=history&feed=atom&title=GABRA3GABRA3 - История изменений2026-10-05T00:36:18ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=GABRA3&diff=5490&oldid=prevOdysseusBot: Новая страница: «Gamma-aminobutyric acid receptor subunit alpha-3 precursor (GABA(A) receptor subunit alpha-3) ==Publications== {{medline-entry |title=Age-related gene-specific...»2021-05-12T13:46:24Z<p>Новая страница: «Gamma-aminobutyric acid receptor subunit alpha-3 precursor (GABA(A) receptor subunit alpha-3) ==Publications== {{medline-entry |title=Age-related gene-specific...»</p>
<p><b>Новая страница</b></p><div>Gamma-aminobutyric acid receptor subunit alpha-3 precursor (GABA(A) receptor subunit alpha-3)<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Age-related gene-specific changes of A-to-I mRNA editing in the human brain.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/20538013<br />
|abstract=A-to-I editing is an adenosine-to-inosine modification of mRNA particularly widespread in the human brain, where it affects thousands of genes. A growing body of evidence suggests that A-to-I RNA editing is necessary for normal development and maintenance in mammals and that its deficiencies contribute to a number of pathological states. In this study, we examined whether mRNA editing levels of two mRNA species, [[CYFIP2]] and [[GABRA3]], change with aging. [[CYFIP2]] has been implicated in synaptic maintenance, while [[GABRA3]] is a GABA receptor subunit, a part of the major inhibitory neurotransmitter system in the CNS. The levels of mRNA editing were assessed in cortex samples of 20 subjects 22-102 years old. The data show an age-dependent statistically significant decrease in editing in [[CYFIP2]]. [[GABRA3]] editing remained much more stable with age, implying that age-related decline of RNA editing is gene-specific. This is the first report of age-dependent decline in A-to-I editing. Further examination of these and other vulnerable genes may reveal specific RNA editing mechanisms that contribute to the aging phenotype.<br />
|mesh-terms=* Adaptor Proteins, Signal Transducing<br />
* Adenosine<br />
* Adult<br />
* Aged<br />
* Aged, 80 and over<br />
* Aging<br />
* Cerebral Cortex<br />
* Female<br />
* Humans<br />
* Inosine<br />
* Male<br />
* Middle Aged<br />
* RNA Editing<br />
* Receptors, GABA-A<br />
* Young Adult<br />
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|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915444<br />
}}</div>OdysseusBot