https://transhumanist.ru/index.php?action=history&feed=atom&title=GABRA2 2026-07-04T23:40:43Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=GABRA2&diff=5759&oldid=prev 2021-05-12T13:58:32Z

<p>Новая страница: «Gamma-aminobutyric acid receptor subunit alpha-2 precursor (GABA(A) receptor subunit alpha-2) ==Publications== {{medline-entry |title=The role of <a href="/GABRA2" title="GABRA2">GABRA2</a> in...»</p> <p><b>Новая страница</b></p><div>Gamma-aminobutyric acid receptor subunit alpha-2 precursor (GABA(A) receptor subunit alpha-2)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=The role of [[GABRA2]] in risk for conduct disorder and alcohol and drug dependence across developmental stages.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16557364<br /> |abstract=We use findings from the behavior genetics literature about how genetic factors (latently) influence alcohol dependence and related disorders to develop and test hypotheses about the risk associated with a specific gene, [[GABRA2]], across different developmental stages. This gene has previously been associated with adult alcohol dependence in the Collaborative Study of the Genetics of Alcoholism (COGA) sample [Edenberg, H. J., Dick, D. M., Xuei, X., Tian, H., Almasy, L., Bauer, L. O., Crowe, R., Goate, A., Hesselbrock, V., Jones, K. A., Kwon, J., Li, T. K., Nurnberger Jr., J. I., O&#039;Connor, S. J., Reich, T., Rice, J., Schuckit, M., Porjesz, B., Foroud, T., and Begleiter, H. (2004). Am. J. Hum. Genet. 74:705-714] and other studies [Covault, J., Gelernter, J., Hesselbrock, V., Nellissery, M., and Kranzler, H. R. (2004). Am. J. Med. Genet. B Neuropsychiatr. Genet. 129B:104-109; Lappalainen, J., Krupitsky, E., Remizov, M., Pchelina, S., Taraskina, A., Zvartau, E., Somberg, L. K., Covault, J., Kranzler, H. R., Krystal, J., and Gelernter, J. (2005). Alcohol. Clin. Exp. Res. 29:493-498]. In a sample of children and adolescents ascertained as part of the COGA project, we find that [[GABRA2]] is significantly associated with childhood conduct disorder symptoms, but not with childhood alcohol dependence symptoms. A consistent elevation in risk for alcohol dependence associated with [[GABRA2]] is not evident until the mid-20s and then remains throughout adulthood. [[GABRA2]] is also associated with other drug dependence in our sample, both in adolescence and adulthood.<br /> |mesh-terms=* Adolescent<br /> * Adult<br /> * Age of Onset<br /> * Aging<br /> * Alcoholism<br /> * Child<br /> * Humans<br /> * Mental Disorders<br /> * Middle Aged<br /> * Receptors, GABA-A<br /> * Regression Analysis<br /> * Risk Factors<br /> * Substance-Related Disorders<br /> * Survival Analysis<br /> * United States<br /> <br /> |full-text-url=https://sci-hub.do/10.1007/s10519-005-9041-8<br /> }}</div>

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