https://transhumanist.ru/index.php?action=history&feed=atom&title=FXYD5 2026-11-09T20:03:00Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=FXYD5&diff=5714&oldid=prev 2021-05-12T13:56:31Z

<p>Новая страница: «FXYD domain-containing ion transport regulator 5 precursor (Dysadherin) [DYSAD] [IWU1] [HSPC113] [UNQ2561/PRO6241] ==Publications== {{medline-entry |title=Reduc...»</p> <p><b>Новая страница</b></p><div>FXYD domain-containing ion transport regulator 5 precursor (Dysadherin) [DYSAD] [IWU1] [HSPC113] [UNQ2561/PRO6241]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Reduced expression of FXYD domain containing ion transport regulator 5 in association with hypertension.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22085977<br /> |abstract=Experimental evidence indicates that hypertension is a multifactorial disorder and that the products of several genes may contribute to its development. The aim of this study was to investigate the expression of hypertension-related genes in spontaneous hypertensive rats (SHRs). A microarray screening for hypertension-related genes was conducted in SHRs and Wistar-Kyoto (WKY) rats using total-RNA extracted from second-order mesenteric arteries and kidneys. The [[FXYD5]] mRNA expression in vascular smooth muscle cells (VSMCs) was silenced by RNA interference (RNAi). Meanwhile, the [[FXYD5]] mRNA overexpression in renal tubular epithelial cells (RTECs) was induced by the recombinant plasmid pcDNA3.1( )-[[FXYD5]]. The expression of [[FXYD5]] mRNA was found to be 14.8-fold lower in SHR rats compared to that in WKY rats (P&lt;0.01). The levels of [[FXYD5]] mRNA expression were the highest in kidneys of SHR 13-week-old rats when the blood pressure reached the highest levels. The down-regulated [[FXYD5]] mRNA expression inhibited the migration of smooth muscle cells (P&lt;0.01) and cell membrane Na⁺-K⁺-ATPase activity (P&lt;0.01). Up-regulated [[FXYD5]] mRNA expression enhanced the renal tubular epithelial cell membrane Na⁺-K⁺-ATPase activity (P&lt;0.05) and cell proliferation (P&lt;0.05). [[FXYD5]] is related to the migration of smooth muscle cells and cell membrane Na⁺-K⁺-ATPase activity in rodents. The results of the present study suggest that [[FXYD5]] may have profound impact on the regulation of blood pressure, and that this gene may be a potential target for anti-hypertensive therapy.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Cell Line<br /> * Cell Movement<br /> * Cell Proliferation<br /> * Gene Expression Profiling<br /> * Gene Expression Regulation<br /> * Genetic Vectors<br /> * Hypertension<br /> * Male<br /> * Membrane Glycoproteins<br /> * Membrane Proteins<br /> * Muscle, Smooth, Vascular<br /> * Myocytes, Smooth Muscle<br /> * RNA, Messenger<br /> * Rats<br /> * Rats, Inbred SHR<br /> * Rats, Inbred WKY<br /> * Sodium-Potassium-Exchanging ATPase<br /> * Transfection<br /> <br /> |full-text-url=https://sci-hub.do/10.3892/ijmm.2011.837<br /> }}</div>

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