https://transhumanist.ru/index.php?action=history&feed=atom&title=FUT8FUT8 - История изменений2026-07-04T20:40:05ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=FUT8&diff=5658&oldid=prevOdysseusBot: Новая страница: «Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Alpha1-6FucT) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fuco...»2021-05-12T13:54:07Z<p>Новая страница: «Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Alpha1-6FucT) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fuco...»</p>
<p><b>Новая страница</b></p><div>Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Alpha1-6FucT) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase)<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Alteration in N-glycomics during mouse aging: a role for [[FUT8]].<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21951615<br />
|abstract=We recently reported that N-glycosylation changes during human aging. To further investigate the molecular basis determining these alterations, the aging process in mice was studied. N-glycan profiling of mouse serum glycoproteins in different age groups of healthy C57BL/6 mice showed substantial age-related changes in three major N-glycan structures: under-galactosylated biantennary (NGA2F), biantennary (NA2), and core α-1,6-fucosylated -β-galactosylated biantennary structures (NA2F). Mice defective in klotho gene expression (kl/kl), which have a shortened lifespan, displayed a similar but accelerated trend. Interestingly, the opposite trend was observed in slow-aging Snell Dwarf mice (dw/dw) and in mice fed a calorically restricted diet. We also discovered that increased expression and activity of α-1,6-fucosyltransferase ([[FUT8]]) in the liver are strongly linked to the age-related changes in glycosylation and that this increased [[FUT8]] and fucosylation influence IGF-1 signaling. These data demonstrate that the glycosylation machinery in liver cells is significantly affected during aging and that age-related increased [[FUT8]] activity could influence the aging process by altering the sensitivity of the IGF-1R signaling pathway.<br />
|mesh-terms=* Aging<br />
* Animals<br />
* Blood Proteins<br />
* Caloric Restriction<br />
* Fucose<br />
* Fucosyltransferases<br />
* Gene Expression<br />
* Glucuronidase<br />
* Glycomics<br />
* Glycoproteins<br />
* Glycosylation<br />
* Insulin-Like Growth Factor I<br />
* Liver<br />
* Male<br />
* Mice<br />
* Mice, Inbred C57BL<br />
* Mice, Transgenic<br />
* Polysaccharides<br />
* Receptor, IGF Type 1<br />
* Signal Transduction<br />
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|full-text-url=https://sci-hub.do/10.1111/j.1474-9726.2011.00749.x<br />
}}</div>OdysseusBot