https://transhumanist.ru/index.php?action=history&feed=atom&title=FMO4 2026-08-29T14:21:14Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=FMO4&diff=5346&oldid=prev 2021-05-12T13:40:05Z

<p>Новая страница: «Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC 1.14.13.8) (Dimethylaniline oxidase 4) (Hepatic flavin-containing monooxygenase 4) (FMO 4) [FMO2] ==Publica...»</p> <p><b>Новая страница</b></p><div>Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC 1.14.13.8) (Dimethylaniline oxidase 4) (Hepatic flavin-containing monooxygenase 4) (FMO 4) [FMO2]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Quantitative analysis of FMO gene mRNA levels in human tissues.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16183778<br /> |abstract=The developmentally and tissue-specific expression of flavin-containing monooxygenase (FMO) enzymes has been previously characterized in a number of animal species, including humans, mice, rats, and rabbits. In this study, we used sensitive real-time reverse transcription-polymerase chain reaction methodology to systematically quantify the steady-state mRNA levels of [[FMO1]], 2, 3, 4, and 5 in human tissues. We examined the developmental regulation of these enzymes in brain tissue. [[FMO1]] was found to be down-regulated in human adult brain. The amount of other FMO mRNAs in human brains in different age groups was not significantly different. The study also provided a systematic quantitative comparison of the steady-state mRNA levels of [[FMO1]] to 5 in several major human organs (i.e., liver, lung, kidney, small intestine, and brain). The nature of the quantitative analysis allowed a comprehensive comparison of each FMO mRNA in different tissues as well as among FMO isoforms in the same tissue. A comparison between fetal liver and adult liver showed that [[FMO1]] was the only FMO that was down-regulated; all other FMOs had greater amounts of mRNA in adult liver. [[FMO5]] was the most prominent FMO form detected in fetal liver. The [[FMO5]] mRNA level was nearly as abundant as [[FMO3]] in adult liver. Whereas other FMOs displayed a significant, dominant tissue-specific mRNA profile (i.e., [[FMO1]] in kidney, [[FMO2]] in lung, [[FMO3]] and [[FMO5]] in adult liver), [[FMO4]] mRNA was observed more broadly at relatively comparable levels in liver, kidney, lung, and small intestine.<br /> |mesh-terms=* Aging<br /> * Brain<br /> * Down-Regulation<br /> * Female<br /> * Humans<br /> * Intestine, Small<br /> * Isoenzymes<br /> * Kidney<br /> * Liver<br /> * Lung<br /> * Male<br /> * Oxygenases<br /> * RNA, Messenger<br /> * Reverse Transcriptase Polymerase Chain Reaction<br /> <br /> |full-text-url=https://sci-hub.do/10.1124/dmd.105.006171<br /> }}</div>

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