https://transhumanist.ru/index.php?action=history&feed=atom&title=FMO2 2026-04-09T03:49:59Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=FMO2&diff=5258&oldid=prev 2021-05-12T13:36:19Z

<p>Новая страница: «Dimethylaniline monooxygenase [N-oxide-forming] 2 (EC 1.14.13.8) (Dimethylaniline oxidase 2) (FMO 1B1) (Pulmonary flavin-containing monooxygenase 2) (FMO 2) ==Pu...»</p> <p><b>Новая страница</b></p><div>Dimethylaniline monooxygenase [N-oxide-forming] 2 (EC 1.14.13.8) (Dimethylaniline oxidase 2) (FMO 1B1) (Pulmonary flavin-containing monooxygenase 2) (FMO 2)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Quantitative analysis of FMO gene mRNA levels in human tissues.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16183778<br /> |abstract=The developmentally and tissue-specific expression of flavin-containing monooxygenase (FMO) enzymes has been previously characterized in a number of animal species, including humans, mice, rats, and rabbits. In this study, we used sensitive real-time reverse transcription-polymerase chain reaction methodology to systematically quantify the steady-state mRNA levels of [[FMO1]], 2, 3, 4, and 5 in human tissues. We examined the developmental regulation of these enzymes in brain tissue. [[FMO1]] was found to be down-regulated in human adult brain. The amount of other FMO mRNAs in human brains in different age groups was not significantly different. The study also provided a systematic quantitative comparison of the steady-state mRNA levels of [[FMO1]] to 5 in several major human organs (i.e., liver, lung, kidney, small intestine, and brain). The nature of the quantitative analysis allowed a comprehensive comparison of each FMO mRNA in different tissues as well as among FMO isoforms in the same tissue. A comparison between fetal liver and adult liver showed that [[FMO1]] was the only FMO that was down-regulated; all other FMOs had greater amounts of mRNA in adult liver. [[FMO5]] was the most prominent FMO form detected in fetal liver. The [[FMO5]] mRNA level was nearly as abundant as [[FMO3]] in adult liver. Whereas other FMOs displayed a significant, dominant tissue-specific mRNA profile (i.e., [[FMO1]] in kidney, [[FMO2]] in lung, [[FMO3]] and [[FMO5]] in adult liver), [[FMO4]] mRNA was observed more broadly at relatively comparable levels in liver, kidney, lung, and small intestine.<br /> |mesh-terms=* Aging<br /> * Brain<br /> * Down-Regulation<br /> * Female<br /> * Humans<br /> * Intestine, Small<br /> * Isoenzymes<br /> * Kidney<br /> * Liver<br /> * Lung<br /> * Male<br /> * Oxygenases<br /> * RNA, Messenger<br /> * Reverse Transcriptase Polymerase Chain Reaction<br /> <br /> |full-text-url=https://sci-hub.do/10.1124/dmd.105.006171<br /> }}<br /> {{medline-entry<br /> |title=Age-related susceptibility to 3,3&#039;-iminodipropionitrile-induced olfactory mucosal damage.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/10192216<br /> |abstract=3,3&#039;-Iminodipropionitrile (IDPN) causes degeneration of the olfactory mucosa (OM) in rodents following systemic exposure. Approximately 30% of the OM degenerates in 21-day- and 10-week-old rats following a single 200 or 400 mg/kg intraperitoneal (i.p.) dose of IDPN, whereas 100% olfactory mucosal degeneration occurred in 21-month-old rats. Age-related changes in the flavin-containing monooxygenases (FMOs) or heat shock protein 70 (HSP70) were hypothesized to be responsible for altered olfactory mucosal susceptibility to IDPN. FMO activity in OM was higher than in liver in rats up to 40 weeks of age. Western blots of OM and liver revealed no change in [[FMO1]] protein; however, [[FMO2]], 3, and 5 decreased in olfactory microsomes with age. [[FMO3]] and [[FMO5]] increased in liver microsomes with age. Heat shock protein 70 did not differ between 10-week- and 10-month-old rats in either tissue. The mechanism underlying the increased susceptibility of older rats is likely a complex interaction between the activities of one or more of the enzymes involved in IDPN metabolism in OM and liver.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Blotting, Western<br /> * Cytosol<br /> * HSP70 Heat-Shock Proteins<br /> * Isoenzymes<br /> * Liver<br /> * Male<br /> * Microsomes<br /> * Nitriles<br /> * Olfactory Mucosa<br /> * Oxygenases<br /> * Rats<br /> <br /> |full-text-url=https://sci-hub.do/10.1016/s0197-4580(98)00104-3<br /> }}</div>

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