https://transhumanist.ru/index.php?action=history&feed=atom&title=FLCN 2026-04-03T22:48:12Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=FLCN&diff=6570&oldid=prev 2021-05-12T15:37:42Z

<p>Новая страница: «Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) [BHD] ==Publications== {{medline-entry |title=Loss of the Birt-Hogg-Dub...»</p> <p><b>Новая страница</b></p><div>Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) [BHD]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23566034<br /> |abstract=Signaling through the hypoxia-inducible factor hif-1 controls longevity, metabolism, and stress resistance in Caenorhabditis elegans. Hypoxia-inducible factor (HIF) protein levels are regulated through an evolutionarily conserved ubiquitin ligase complex. Mutations in the [[VHL]] gene, encoding a core component of this complex, cause a multitumor syndrome and renal cell carcinoma in humans. In the nematode, deficiency in vhl-1 promotes longevity mediated through HIF-1 stabilization. However, this longevity assurance pathway is not yet understood. Here, we identify folliculin ([[FLCN]]) as a novel interactor of the hif-1/vhl-1 longevity pathway. [[FLCN]] mutations cause Birt-Hogg-Dubé syndrome in humans, another tumor syndrome with renal tumorigenesis reminiscent of the [[VHL]] disease. Loss of the C. elegans ortholog of [[FLCN]] F22D3.2 significantly increased lifespan and enhanced stress resistance in a hif-1-dependent manner. F22D3.2, vhl-1, and hif-1 control longevity by a mechanism distinct from insulin-like signaling. Daf-16 deficiency did not abrogate the increase in lifespan mediated by flcn-1. These findings define [[FLCN]] as a player in HIF-dependent longevity signaling and connect organismal aging, stress resistance, and regulation of longevity with the formation of renal cell carcinoma.<br /> |mesh-terms=* Animals<br /> * Birt-Hogg-Dube Syndrome<br /> * Caenorhabditis elegans<br /> * Caenorhabditis elegans Proteins<br /> * Cullin Proteins<br /> * Forkhead Transcription Factors<br /> * Gene Expression Regulation, Developmental<br /> * Humans<br /> * Longevity<br /> * Mutation<br /> * Protein Stability<br /> * Proto-Oncogene Proteins<br /> * RNA, Messenger<br /> * Sequence Homology, Amino Acid<br /> * Transcription Factors<br /> * Tumor Suppressor Proteins<br /> |keywords=* Birt-Hogg-Dubé<br /> * C. elegans<br /> * Vhl<br /> * folliculin<br /> * hif<br /> * longevity<br /> |full-text-url=https://sci-hub.do/10.1111/acel.12081<br /> }}</div>

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