https://transhumanist.ru/index.php?action=history&feed=atom&title=FGF20FGF20 - История изменений2026-05-19T01:01:56ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=FGF20&diff=5353&oldid=prevOdysseusBot: Новая страница: «Fibroblast growth factor 20 (FGF-20) ==Publications== {{medline-entry |title=Genetic variation in FGF20 modulates hippocampal biology. |pubmed-url=https://p...»2021-05-12T13:40:22Z<p>Новая страница: «Fibroblast growth factor 20 (FGF-20) ==Publications== {{medline-entry |title=Genetic variation in <a href="/FGF20" title="FGF20">FGF20</a> modulates hippocampal biology. |pubmed-url=https://p...»</p>
<p><b>Новая страница</b></p><div>Fibroblast growth factor 20 (FGF-20)<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Genetic variation in [[FGF20]] modulates hippocampal biology.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/20427658<br />
|abstract=We explored the effect of single-nucleotide polymorphisms (SNPs) in the fibroblast growth factor 20 gene ([[FGF20]]) associated with risk for Parkinson's disease on brain structure and function in a large sample of healthy young-adult human subjects and also in elderly subjects to look at the interaction between genetic variations and age (N = 237; 116 men; 18-87 years). We analyzed high-resolution anatomical magnetic resonance images using voxel-based morphometry, a quantitative neuroanatomical technique. We also measured [[FGF20]] mRNA expression in postmortem human brain tissue to determine the molecular correlates of these SNPs (N = 108; 72 men; 18-74 years). We found that the T allele carriers of rs12720208 in the 3'-untranslated region had relatively larger hippocampal volume (p = 0.0059) and diminished verbal episodic memory (p = 0.048) and showed steeper decreases of hippocampal volume with normal aging (p = 0.026). In postmortem brain, T allele carriers had greater expression of hippocampal [[FGF20]] mRNA (p = 0.037), consistent with a previously characterized microRNA mechanism. The C allele matches a predicted miR-433 microRNA binding domain, whereas the T allele disrupts it, resulting in higher [[FGF20]] protein translation. The strong [[FGF20]] genetic effects in hippocampus are presumably mediated by activation of the [[FGFR1]] (FGF receptor 1), which is expressed in mammalian brain most abundantly in the hippocampus. These associations, from mRNA expression to brain morphology to cognition and an interaction with aging, confirm a role of [[FGF20]] in human brain structure and function during development and aging.<br />
|mesh-terms=* Adolescent<br />
* Adult<br />
* Aged<br />
* Aged, 80 and over<br />
* Aging<br />
* Alleles<br />
* Cognition<br />
* Female<br />
* Fibroblast Growth Factors<br />
* Genotype<br />
* Hippocampus<br />
* Humans<br />
* Male<br />
* MicroRNAs<br />
* Middle Aged<br />
* Organ Size<br />
* Polymorphism, Single Nucleotide<br />
* RNA, Messenger<br />
* Receptor, Fibroblast Growth Factor, Type 1<br />
* Young Adult<br />
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|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909689<br />
}}</div>OdysseusBot