https://transhumanist.ru/index.php?action=history&feed=atom&title=FGF14 2026-04-07T15:10:24Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=FGF14&diff=6549&oldid=prev 2021-05-12T15:36:35Z

<p>Новая страница: «Fibroblast growth factor 14 (FGF-14) (Fibroblast growth factor homologous factor 4) (FHF-4) [FHF4] ==Publications== {{medline-entry |title=Fibroblast Growth Fac...»</p> <p><b>Новая страница</b></p><div>Fibroblast growth factor 14 (FGF-14) (Fibroblast growth factor homologous factor 4) (FHF-4) [FHF4]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Fibroblast Growth Factor 14 Modulates the Neurogenesis of Granule Neurons in the Adult Dentate Gyrus.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26687232<br /> |abstract=Adult neurogenesis, the production of mature neurons from progenitor cells in the adult mammalian brain, is linked to the etiology of neurodegenerative and psychiatric disorders. However, a thorough understanding of the molecular elements at the base of adult neurogenesis remains elusive. Here, we provide evidence for a previously undescribed function of fibroblast growth factor 14 ([[FGF14]]), a brain disease-associated factor that controls neuronal excitability and synaptic plasticity, in regulating adult neurogenesis in the dentate gyrus (DG). We found that [[FGF14]] is dynamically expressed in restricted subtypes of sex determining region Y-box 2 (Sox2)-positive and doublecortin ([[DCX]])-positive neural progenitors in the DG. Bromodeoxyuridine (BrdU) incorporation studies and confocal imaging revealed that genetic deletion of Fgf14 in Fgf14 mice leads to a significant change in the proportion of proliferating and immature and mature newly born adult granule cells. This results in an increase in the late immature and early mature population of [[DCX]] and calretinin (CR)-positive neurons. Electrophysiological extracellular field recordings showed reduced minimal threshold response and impaired paired-pulse facilitation at the perforant path to DG inputs in Fgf14 compared to Fgf14 mice, supporting disrupted synaptic connectivity as a correlative read-out to impaired neurogenesis. These new insights into the biology of [[FGF14]] in neurogenesis shed light into the signaling pathways associated with disrupted functions in complex brain diseases.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Animals, Newborn<br /> * Apoptosis<br /> * Cell Count<br /> * Cell Differentiation<br /> * Cell Survival<br /> * Cytoplasmic Granules<br /> * Dentate Gyrus<br /> * Female<br /> * Fibroblast Growth Factors<br /> * Gene Deletion<br /> * Gene Expression Profiling<br /> * Male<br /> * Mice, Inbred C57BL<br /> * Microtubule-Associated Proteins<br /> * Neural Stem Cells<br /> * Neurogenesis<br /> * Neurons<br /> * Neuropeptides<br /> * Synapses<br /> |keywords=* Adult neurogenesis<br /> * Ataxia<br /> * Axon initial segment<br /> * FGF14<br /> * Growth factors<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916041<br /> }}</div>

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