https://transhumanist.ru/index.php?action=history&feed=atom&title=FGF1 2026-06-15T17:45:41Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=FGF1&diff=5387&oldid=prev 2021-05-12T13:41:47Z

<p>Новая страница: «Fibroblast growth factor 1 precursor (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (H...»</p> <p><b>Новая страница</b></p><div>Fibroblast growth factor 1 precursor (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (HBGF-1) [FGFA]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Attenuation of FGF signalling in mouse beta-cells leads to diabetes.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/11130726<br /> |abstract=Fibroblast growth factor (FGF) signalling has been implicated in patterning, proliferation and cell differentiation in many organs, including the developing pancreas. Here we show that the FGF receptors (FGFRs) 1 and 2, together with the ligands [[FGF1]], [[FGF2]], [[FGF4]], [[FGF5]], [[FGF7]] and [[[[FGF1]]0]], are expressed in adult mouse beta-cells, indicating that FGF signalling may have a role in differentiated beta-cells. When we perturbed signalling by expressing dominant-negative forms of the receptors, [[FGFR1]]c and FGFR2b, in the pancreas, we found that that mice with attenuated [[FGFR1]]c signalling, but not those with reduced FGFR2b signalling, develop diabetes with age and exhibit a decreased number of beta-cells, impaired expression of glucose transporter 2 and increased proinsulin content in beta-cells owing to impaired expression of prohormone convertases 1/3 and 2. These defects are all characteristic of patients with type-2 diabetes. Mutations in the homeobox gene Ipf1/Pdx1 are linked to diabetes in both mouse and human. We also show that Ipf1/Pdx1 is required for the expression of [[FGFR1]] signalling components in beta-cells, indicating that Ipf1/Pdx1 acts upstream of [[FGFR1]] signalling in beta-cells to maintain proper glucose sensing, insulin processing and glucose homeostasis.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Blood Glucose<br /> * Diabetes Mellitus, Experimental<br /> * Diabetes Mellitus, Type 2<br /> * Fibroblast Growth Factors<br /> * Glucose Transporter Type 1<br /> * Glucose Transporter Type 2<br /> * Homeodomain Proteins<br /> * Humans<br /> * Insulin<br /> * Islets of Langerhans<br /> * Mice<br /> * Mice, Transgenic<br /> * Monosaccharide Transport Proteins<br /> * Pancreas<br /> * Receptor Protein-Tyrosine Kinases<br /> * Receptor, Fibroblast Growth Factor, Type 1<br /> * Receptor, Fibroblast Growth Factor, Type 2<br /> * Receptors, Fibroblast Growth Factor<br /> * Signal Transduction<br /> * Trans-Activators<br /> <br /> |full-text-url=https://sci-hub.do/10.1038/35048589<br /> }}</div>

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