https://transhumanist.ru/index.php?action=history&feed=atom&title=FBXO7FBXO7 - История изменений2026-08-29T14:59:48ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=FBXO7&diff=6539&oldid=prevOdysseusBot: Новая страница: «F-box only protein 7 [FBX7] ==Publications== {{medline-entry |title=The FBXO7 homologue nutcracker and binding partner PI31 in Drosophila melanogaster model...»2021-05-12T15:36:01Z<p>Новая страница: «F-box only protein 7 [FBX7] ==Publications== {{medline-entry |title=The <a href="/FBXO7" title="FBXO7">FBXO7</a> homologue nutcracker and binding partner PI31 in Drosophila melanogaster model...»</p>
<p><b>Новая страница</b></p><div>F-box only protein 7 [FBX7]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=The [[FBXO7]] homologue nutcracker and binding partner PI31 in Drosophila melanogaster models of Parkinson's disease.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27936908<br />
|abstract=Parkinsonian-pyramidal syndrome (PPS) is an early onset form of Parkinson's disease (PD) that shows degeneration of the extrapyramidal region of the brain to result in a severe form of PD. The toxic protein build-up has been implicated in the onset of PPS. Protein removal is mediated by an intracellular proteasome complex: an E3 ubiquitin ligase, the targeting component, is essential for function. [[FBXO7]] encodes the F-box component of the SCF E3 ubiquitin ligase linked to familial forms of PPS. The Drosophila melanogaster homologue nutcracker (ntc) and a binding partner, PI31, have been shown to be active in proteasome function. We show that altered expression of either ntc or PI31 in dopaminergic neurons leads to a decrease in longevity and locomotor ability, phenotypes both associated with models of PD. Furthermore, expression of ntc-RNAi in an established α-synuclein-dependent model of PD rescues the phenotypes of diminished longevity and locomotor control.<br />
|mesh-terms=* Animals<br />
* Animals, Genetically Modified<br />
* Carrier Proteins<br />
* Disease Models, Animal<br />
* Drosophila Proteins<br />
* Drosophila melanogaster<br />
* Eye<br />
* F-Box Proteins<br />
* Female<br />
* Gene Expression<br />
* Longevity<br />
* Male<br />
* Organ Specificity<br />
* Organogenesis<br />
* Parkinson Disease<br />
* Protein Binding<br />
* Protein Interaction Domains and Motifs<br />
* alpha-Synuclein<br />
|keywords=* Drosophila melanogaster<br />
* FBXO7<br />
* PI31<br />
* Parkinson Disease<br />
* maladie de Parkinson<br />
* neurodegeneration<br />
* neurodégénérescence<br />
* nutcracker<br />
|full-text-url=https://sci-hub.do/10.1139/gen-2016-0087<br />
}}</div>OdysseusBot