https://transhumanist.ru/index.php?action=history&feed=atom&title=FAIMFAIM - История изменений2026-04-11T09:43:33ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=FAIM&diff=5176&oldid=prevOdysseusBot: Новая страница: «Fas apoptotic inhibitory molecule 1 [FAIM1] ==Publications== {{medline-entry |title=B cells from aged mice exhibit reduced apoptosis upon B-cell antigen recepto...»2021-05-12T13:32:37Z<p>Новая страница: «Fas apoptotic inhibitory molecule 1 [FAIM1] ==Publications== {{medline-entry |title=B cells from aged mice exhibit reduced apoptosis upon B-cell antigen recepto...»</p>
<p><b>Новая страница</b></p><div>Fas apoptotic inhibitory molecule 1 [FAIM1]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=B cells from aged mice exhibit reduced apoptosis upon B-cell antigen receptor stimulation and differential ability to up-regulate survival signals.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16367931<br />
|abstract=During ageing, autoimmune disorders and the higher susceptibility to infectious have been associated with alterations in the humoral immune response. We report that splenic B lymphocytes from aged mice exhibit lower level of apoptosis induced by B-cell antigen receptor ([[BCR]]) ligation in vitro. Respect to B cells from young mice the anti-mu stimulated aged B cells show similar Bcl-2 and Bcl-xL expression but differential kinetic of A1 degradation and a higher level of cFLIP and [[FAIM]]. Even though B cells from aged mice show minor Fas expression they exhibit the same susceptibility to anti-Fas induced apoptosis. Aged B cells also present upon [[BCR]] stimulation, a higher proliferative response and similar level of activation markers expression than B cells from young mice. These data agree with the observation that aged mice exhibit an increment of T2 and mature B cell subset which rapidly enters cell cycle upon [[BCR]] engagement. The diminished apoptosis after activation in aged mice could compromise homeostatic mechanism allowing the persistence of self and non-self antigen specific B cells.<br />
|mesh-terms=* Aging<br />
* Animals<br />
* Antigens<br />
* Apoptosis<br />
* Apoptosis Regulatory Proteins<br />
* B-Lymphocyte Subsets<br />
* Biomarkers<br />
* Blotting, Western<br />
* CASP8 and FADD-Like Apoptosis Regulating Protein<br />
* Cell Survival<br />
* Cells, Cultured<br />
* Electrophoresis, Polyacrylamide Gel<br />
* Female<br />
* Flow Cytometry<br />
* Inhibitor of Apoptosis Proteins<br />
* Intracellular Signaling Peptides and Proteins<br />
* Mice<br />
* Mice, Inbred BALB C<br />
* Receptors, Antigen, B-Cell<br />
* Reverse Transcriptase Polymerase Chain Reaction<br />
* Signal Transduction<br />
* Up-Regulation<br />
* fas Receptor<br />
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|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809574<br />
}}</div>OdysseusBot