https://transhumanist.ru/index.php?action=history&feed=atom&title=EXT2 2026-10-02T03:55:35Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=EXT2&diff=5120&oldid=prev 2021-05-12T13:30:04Z

<p>Новая страница: «Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferas...»</p> <p><b>Новая страница</b></p><div>Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2) (Putative tumor suppressor protein EXT2)<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Gene expression of [[EXT1]] and [[EXT2]] during mouse brain development.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/12644256<br /> |abstract=Heparan sulfate (HS) and heparan sulfate proteoglycans (HSPGs) play significant roles in various biological processes. There is a wealth of circumstantial and experimental evidence suggesting the roles of HS in mammalian neural development. HS synthesis is governed by a series of enzymes. Among them, two enzymes, [[EXT1]] and [[EXT2]], catalyze polymerization of glucuronic acid and N-acetylglucosamine, the crucial step of HS synthesis. To obtain insight into the roles of HS in neural development, we examined the spatiotemporal expression patterns of [[EXT1]] and [[EXT2]] during mice brain development. RT-PCR analyses showed that expression of [[EXT1]] and [[EXT2]] peaks during early postnatal period in the cerebrum and around birth in the cerebellum. In situ hybridization revealed that in the embryonic brain, [[EXT1]] and [[EXT2]] were localized primarily in the neuroepithelial cells surrounding the lateral ventricles, the mesencephalic vesicle, and the fourth ventricle. In the early postnatal stage, intense expression of [[EXT1]] and [[EXT2]] was observed in the cerebral cortex and the hippocampus formation. In the postnatal cerebellum, expression of [[EXT1]] and [[EXT2]] was mainly observed in external and internal granular layers. Our results demonstrate that [[EXT1]] and [[EXT2]] are highly expressed in the developing brain, and that their expression is developmentally regulated, suggesting that HS is involved in various neurodevelopmental processes.<br /> |mesh-terms=* Aging<br /> * Animals<br /> * Animals, Newborn<br /> * Brain<br /> * Cell Differentiation<br /> * Cerebellum<br /> * Fetus<br /> * Gene Expression Regulation, Developmental<br /> * Gene Expression Regulation, Enzymologic<br /> * Heparitin Sulfate<br /> * Hippocampus<br /> * Lateral Ventricles<br /> * Mice<br /> * Mice, Inbred C57BL<br /> * N-Acetylglucosaminyltransferases<br /> * Neurons<br /> * RNA, Messenger<br /> * Stem Cells<br /> * Telencephalon<br /> <br /> |full-text-url=https://sci-hub.do/10.1016/s0165-3806(03)00010-5<br /> }}</div>

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