https://transhumanist.ru/index.php?action=history&feed=atom&title=ESAMESAM - История изменений2026-11-08T15:00:26ZИстория изменений этой страницы в викиMediaWiki 1.43.6https://transhumanist.ru/index.php?title=ESAM&diff=5238&oldid=prevOdysseusBot: Новая страница: «Endothelial cell-selective adhesion molecule precursor [UNQ220/PRO246] ==Publications== {{medline-entry |title=The endothelial antigen ESAM marks primitive...»2021-05-12T13:35:29Z<p>Новая страница: «Endothelial cell-selective adhesion molecule precursor [UNQ220/PRO246] ==Publications== {{medline-entry |title=The endothelial antigen <a href="/ESAM" title="ESAM">ESAM</a> marks primitive...»</p>
<p><b>Новая страница</b></p><div>Endothelial cell-selective adhesion molecule precursor [UNQ220/PRO246]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=The endothelial antigen [[ESAM]] marks primitive hematopoietic progenitors throughout life in mice.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/19096010<br />
|abstract=Although recent advances have enabled hematopoietic stem cells (HSCs) to be enriched to near purity, more information about their characteristics will improve our understanding of their development and stage-related functions. Here, using microarray technology, we identified endothelial cell-selective adhesion molecule ([[ESAM]]) as a novel marker for murine HSCs in fetal liver. Esam was expressed at high levels within a Rag1(-) c-kit(Hi) Sca1( ) HSC-enriched fraction, but sharply down-regulated with activation of the Rag1 locus, a valid marker for the most primitive lymphoid progenitors in E14.5 liver. The HSC-enriched fraction could be subdivided into 2 on the basis of [[ESAM]] levels. Among endothelial antigens on hematopoietic progenitors, [[ESAM]] expression showed intimate correlation with HSC activity. The [[ESAM]](Hi) population was highly enriched for multipotent myeloid-erythroid progenitors and primitive progenitors with lymphopoietic activity, and exclusively reconstituted long-term lymphohematopoiesis in lethally irradiated recipients. Tie2( ) c-kit( ) lymphohematopoietic cells in the E9.5-10.5 aorta-gonad-mesonephros region also expressed high levels of [[ESAM]]. Furthermore, [[ESAM]] was detected on primitive hematopoietic progenitors in adult bone marrow. Interestingly, [[ESAM]] expression in the HSC-enriched fraction was up-regulated in aged mice. We conclude that [[ESAM]] marks HSC in murine fetal liver and will facilitate studies of hematopoiesis throughout life.<br />
|mesh-terms=* Aging<br />
* Animals<br />
* Biomarkers<br />
* Cell Adhesion Molecules<br />
* Cells, Cultured<br />
* Embryo, Mammalian<br />
* Endothelial Cells<br />
* Female<br />
* Fetus<br />
* Gene Expression Profiling<br />
* Gene Expression Regulation, Developmental<br />
* Gene Knock-In Techniques<br />
* Hematopoiesis<br />
* Hematopoietic Stem Cells<br />
* Liver<br />
* Male<br />
* Mice<br />
* Mice, Inbred C57BL<br />
* Mice, Transgenic<br />
* Oligonucleotide Array Sequence Analysis<br />
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|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974489<br />
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