https://transhumanist.ru/index.php?action=history&feed=atom&title=ENTPD1 2026-06-15T01:27:56Z История изменений этой страницы в вики MediaWiki 1.43.6 https://transhumanist.ru/index.php?title=ENTPD1&diff=6478&oldid=prev 2021-05-12T15:32:41Z

<p>Новая страница: «Ectonucleoside triphosphate diphosphohydrolase 1 (EC 3.6.1.5) (NTPDase 1) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoi...»</p> <p><b>Новая страница</b></p><div>Ectonucleoside triphosphate diphosphohydrolase 1 (EC 3.6.1.5) (NTPDase 1) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (CD39 antigen) [CD39]<br /> <br /> ==Publications==<br /> <br /> {{medline-entry<br /> |title=Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation.<br /> |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32452837<br /> |abstract=Vaccination is a mainstay in preventive medicine, reducing morbidity and mortality from infection, largely by generating pathogen-specific neutralizing antibodies. However, standard immunization strategies are insufficient with increasing age due to immunological impediments, including defects in T follicular helper (Tfh) cells. Here, we found that Tfh generation is inversely linked to the expression of the ecto-NTPDase CD39 that modifies purinergic signaling. The lineage-determining transcription factor [[BCL6]] inhibited CD39 expression, while increased Tfh frequencies were found in individuals with a germline polymorphism preventing transcription of [[ENTPD1]], encoding CD39. In in vitro human and in vivo mouse studies, Tfh generation and germinal center responses were enhanced by reducing CD39 expression through the inhibition of the cAMP/PKA/p-CREB pathway, or by blocking adenosine signaling downstream of CD39 using the selective adenosine A2a receptor antagonist istradefylline. Thus, purinergic signaling in differentiating T cells can be targeted to improve vaccine responses, in particular in older individuals who have increased CD39 expression.<br /> <br /> |keywords=* Adaptive immunity<br /> * Aging<br /> * Cellular senescence<br /> * T cells<br /> * Vaccines<br /> |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324201<br /> }}</div>

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